AUTHOR=Gridina Maria , Fishman Veniamin 

TITLE=Multilevel view on chromatin architecture alterations in cancer

JOURNAL=Frontiers in Genetics

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.1059617

DOI=10.3389/fgene.2022.1059617

ISSN=1664-8021

ABSTRACT=Chromosomes are not located inside the nucleus in the form of linear molecules. Instead, there is a complex multilevel genome folding that includes nucleosomes, topologically associating domains, compartments, and finally, chromosomal territories. Proper spatial organization is essential for the correct functioning of the genome, and is therefore subject to change during development or disease. Here we discuss exactly how the organization of the cancer cell genome is different from the healthy genome on various levels. A better understanding of how malignization affects genome organization and long-range gene regulation will help reveal the molecular mechanisms underlying cancer development and evolution.