AUTHOR=Zhou Xijia , Tian Chang , Cao Yingshu , Zhao Min , Wang Ke 

TITLE=The role of serine metabolism in lung cancer: From oncogenesis to tumor treatment

JOURNAL=Frontiers in Genetics

VOLUME=13

YEAR=2023

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.1084609

DOI=10.3389/fgene.2022.1084609

ISSN=1664-8021

ABSTRACT=<p>Metabolic reprogramming is an important hallmark of malignant tumors. Serine is a non-essential amino acid involved in cell proliferation. Serine metabolism, especially the <italic>de novo</italic> serine synthesis pathway, forms a metabolic network with glycolysis, folate cycle, and one-carbon metabolism, which is essential for rapidly proliferating cells. Owing to the rapid development in metabolomics, abnormal serine metabolism may serve as a biomarker for the early diagnosis and pathological typing of tumors. Targeting serine metabolism also plays an essential role in precision and personalized cancer therapy. This article is a systematic review of <italic>de novo</italic> serine biosynthesis and the link between serine and folate metabolism in tumorigenesis, particularly in lung cancer. In addition, we discuss the potential of serine metabolism to improve tumor treatment.</p>