AUTHOR=Yang Ying , Xiao Jingxin , Tang Lingling , Wang Bohan , Sun Xianhong , Xu Zhongchi , Liu Li , Shi Suofang 

TITLE=Effects of IL-6 Polymorphisms on Individual Susceptibility to Allergic Diseases: A Systematic Review and Meta-Analysis

JOURNAL=Frontiers in Genetics

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.822091

DOI=10.3389/fgene.2022.822091

ISSN=1664-8021

ABSTRACT=Background: Many studies have assessed the potential link between interleukin-6 polymorphisms and susceptibility to allergic diseases. However, the results are still conflicting. Therefore, a comprehensive meta-analysis can not only resolve differences but also provide clues for future projects.
Methods: A systematic electronic search was conducted on the databases of Web of Science, PubMed and Cochrane Library to retrieve all published studies. Revman and Stata software were used for statistical analysis.
Results: This meta-analysis included 11 studies. The results revealed that there was no statistically significant correlation between IL-6 polymorphisms with allergic diseases risk in general population. Subgroup analyses demonstrated that rs1800795 affected allergic diseases risk in different populations. 
Conclusions: Our findings suggested that IL-6 rs1800795 was associated with allergic diseases susceptibility among Asians and Caucasians in opposite trends, and it might influence the risk of asthma and allergic rhinitis. None of IL-6 polymorphisms were shared risk variants of allergic diseases.