AUTHOR=Yang Shifeng , Zou Xiaoming , Yang Hao , Li Jiacheng , Zhang Ange , Zhang Lisha , Li Changjian , Zhu Lei , Ma Zhen 

TITLE=Identification of Enhancer RNA CDK6-AS1 as a Potential Novel Prognostic Biomarker in Gastric Cancer

JOURNAL=Frontiers in Genetics

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.854211

DOI=10.3389/fgene.2022.854211

ISSN=1664-8021

ABSTRACT=Background:
The aim of this study was to confirm enhancer RNAs (eRNAs)    in gastric cancer and its clincial utility.
Methods:
We used cox survival analysis and relevance analysis to identify the candidate eRNAs in gastric cancer. Moreover, we performed GO and Reactome pathway enrichment to found the potential functions of eRNAs.Correlation between eRNA, tumor-infiltrating immune cells and drug sensitivity was then analyzed.
Results:
CDK6-AS1  may  serve  as  a  poor  independent  prognostic  biomarker  candidate  in gastric cancer with positive correlation with its target gene CDK6. Low CDK6-AS1 expression group showed more frequent mutated driver genes than high expression ones. Moreover, CDK6-AS1 is involved in key oncogenic pathway as cell cycle and RNA  transcription.  CDK6-AS1  also  shows  dysregulations  and  associations  with prognosis  at pan-cancer  level.  This  eRNA may  also  associated with  immune  cell infiltration and drug sensitivity.
Conclusion:
CDK6-AS1  may  be  a  potential  prognostic  biomarker  for  gastric  cancer,  predict chemotherapeutic drugs sensitivity of gastric cancer.