AUTHOR=Li Jingru , Li Chaozhong , Zhao Yulan , Wu Xinyu , Yu Shuai , Sun Guihu , Ding Peng , Lu Si , Zhang Lijiao , Yang Ping , Peng Yunzhu , Fu Jingyun , Wang Luqiao 

TITLE=Integrated bioinformatics analysis for novel miRNAs markers and ceRNA network in diabetic retinopathy

JOURNAL=Frontiers in Genetics

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.874885

DOI=10.3389/fgene.2022.874885

ISSN=1664-8021

ABSTRACT=We aimed to find miRNAs biomarkers for diabetic retinopathy (DR) and to explore the mechanisms in this pathology via bioinformatics analyses. Method: Based on public omics data and databases, we investigated ncRNA (non-coding RNA) functions based on ceRNA hypothesis. Result: Among differentially expressed miRNAs (DE-miRNAs), hsa-miR-4797-3p and -665 may be diagnosis biomarkers of DR. Functional enrichment analysis revealed differentially expressed mRNAs (DE-mRNAs) enriched in mitochondrial transport, cellular respiration and energy derivation. 18 tissue/organ-specific expressed genes, 10 hub genes and gene cluster modules were identified. The ceRNA networks lncRNA FBXL19-AS1/miR-378f/MRPL39 and lncRNA UBL7-AS1/miR-378f/MRPL39 might be potential RNA regulatory pathways in DR. Conclusions: miR-4797-3p and -665 can be used as diagnostic markers of DR, and lncRNA FBXL19-AS1/UBL7-AS1-miR-378f-MRPL39 plays an important role in the progression of DR.