AUTHOR=Chuang Chih-Chun , Yang Yi-Sun , Kornelius Edy , Huang Chien-Ning , Hsu Min-Yen , Lee Chia-Yi , Yang Shun-Fa 

TITLE=Impact of Long Noncoding RNA LINC00673 Genetic Variants on Susceptibility to Diabetic Retinopathy

JOURNAL=Frontiers in Genetics

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.889530

DOI=10.3389/fgene.2022.889530

ISSN=1664-8021

ABSTRACT=Long noncoding RNAs (lncRNAs) have been proven to play critical roles in diabetic retinopathy (DR). This study investigated whether the single nucleotide polymorphism (SNP) of long intergenic noncoding RNA 00673 (LINC00673) affect the clinical characteristics of diabetic retinopathy (DR). Three loci of LINC00673 SNPs (rs6501551, rs9914618, and rs11655237) were genotyped using TaqMan allelic discrimination in 276 and 454 individuals with and without DR, respectively. Our results revealed that LINC00673 SNP rs11655237 CT genotype (AOR: 1.592, 95% CI: 1.059–2.395, P = 0.026), CT+TT genotype (AOR: 1.255, 95% CI: 1.029–1.531, P = 0.025), and allele T (AOR: 1.185, 95% CI: 1.004–1.397, P = 0.044) yielded higher ratios in the nonproliferative diabetic retinopathy (NPDR) subgroup than in the non-DR group. Furthermore, the interval of diabetes mellitus (DM) was significantly shorter in the LINC00673 SNP rs11655237 CT+TT variant than in the LINC00673 SNP rs11655237 wild type (10.44 ± 7.10 versus 12.98 ± 8.34, P = 0.009). In conclusion, the LINC00673 SNP rs11655237 T allele is associated with a higher probability of NPDR development. Patients with the LINC00673 SNP rs11655237 CT+TT variant exhibited a short DM interval.