AUTHOR=Yang Heng , Chiang Chengyao , Luo Qinhong , Chen Chunlan , Huang Junrong , Zhu Lizhi , Zheng Duo 

TITLE=YT521-B homology domain family proteins as N6-methyladenosine readers in tumors

JOURNAL=Frontiers in Genetics

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.934223

DOI=10.3389/fgene.2022.934223

ISSN=1664-8021

ABSTRACT=N6-methyladenosine (m6A) is the most abundant internal mRNA modification in eukaryotes and plays diverse roles in gene regulation. The m6A modification plays a significant role in numerous cancer types, including kidney, stomach, lung, bladder tumors, and melanoma by varied mechanisms. As direct m6A readers, the YT521-B homology domain family proteins (YTHDFs) play a key role in tumor transcription, translation, protein synthesis, tumor stemness, immune escape, epithelial-mesenchymal transition (EMT) and chemotherapy resistance. An in-depth understanding of the molecular mechanism of YTHDFs is expected to provide new strategies for tumor treatment. In this review, we provide a systematic description of YTHDF protein structure and their function in tumor progression.