AUTHOR=Tian Yu , Wu Xiaochuan , Li Yongzhen , He Wenbin , Liu Zibin , Myers Frank L. , Zhou Liang 

TITLE=Case report: Unilateral panuveitis as a manifestation of Alport syndrome in a Chinese pediatric patient

JOURNAL=Frontiers in Genetics

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.934829

DOI=10.3389/fgene.2022.934829

ISSN=1664-8021

ABSTRACT=Purpose: To report a rare case of a patient with Alport syndrome which was manifested as unilateral non-infectious uveitis after bilateral cataract surgery.
Methods: A case report
Results: A 2-year-old boy was diagnosed with unilateral uveitis based on the opacified vitreous and leakage of fluorescein angiography. Gene analysis and culture for the pathogen were negative. However, urine tests found blood cells and kidney pathology revealed a thickened membrane. A diagnosis of Alport syndrome was made. The patient was treated with oral steroids. The uveitis resolved gradually.
Conclusion: Uveitis may be an ocular manifestation of Alport syndrome.
Keywords: Alport syndrome, uveitis, COL4A5, pediatric, collagen