AUTHOR=Chen Hui-Ming , Li Hang , Lin Meng-Xian , Fan Wei-Jie , Zhang Yi , Lin Yan-Ting , Wu Shu-Xiang 

TITLE=Research Progress for RNA Modifications in Physiological and Pathological Angiogenesis

JOURNAL=Frontiers in Genetics

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.952667

DOI=10.3389/fgene.2022.952667

ISSN=1664-8021

ABSTRACT=As a critical layer of epigenetics, RNA modifications have a variety of molecular functions and participate in numerous biological processes. RNA modifications have been shown to be essential for embryogenesis and stem cell fate. As high-throughput sequencing and antibody technologies have advanced by leaps and bounds, the association of RNA modifications with multiple human diseases have sparked research enthusiasm; additionally, aberrant RNA modification leads to tumor angiogenesis by regulating angiogenesis-related factors. This review collected recent cutting-edge studies focus on RNA modifications (N6-methyladenosine (m6A), N5-methylcytosine (m5C), N7-methylguanosine (m7G), N1-methyladenosine (m1A), and pseudopuridine (Ψ)), and their related regulators in tumor angiogenesis. to emphasize the role and impact of RNA modifications.