AUTHOR=Sun Shulei , Shen Yuehao , Feng Jing 

TITLE=Association of toll-like receptors polymorphisms with COPD risk in Chinese population

JOURNAL=Frontiers in Genetics

VOLUME=13

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.955810

DOI=10.3389/fgene.2022.955810

ISSN=1664-8021

ABSTRACT=<p><bold>Background:</bold> Previous studies have reported that the Toll-like receptors (TLRs) are related with the progress of chronic obstructive pulmonary disease (COPD). We aimed to explore the association of TLRs single nucleotide polymorphisms (SNPs) and COPD risk.</p><p><bold>Methods:</bold> 170 COPD patients and 181 healthy controls were enrolled in this case-control study. MassARRAY platform was used for genotyping seven tagging SNPs (<italic>TLR2</italic>: rs3804100, rs4696480, rs3804099; <italic>TLR3</italic>: rs3775290, rs3775291, rs5743305; <italic>TLR9</italic>: rs352140) of TLRs. The correlations between the SNPs and COPD risk were determined using logistic regression.</p><p><bold>Results:</bold> We found that the rs3775291 of <italic>TLR3</italic> significant decreased the risk of COPD (TT <italic>versus</italic> CC: non-adjusted OR = 0.329, 95% CI = 0.123–0.879, <italic>p</italic> = 0.027). In the genetic models analysis, the rs3775291 was associated with a decreased effect of COPD based on the recessive model (TT <italic>versus</italic> CC/CT: non-adjusted OR = 0.377, 95% CI = 0.144–0.988 <italic>p</italic> = 0.047). The rs4696480 of <italic>TLR2</italic> gene was associated with a decreased risk of COPD after adjustment by age and gender (TA <italic>versus</italic> AA: adjusted OR = 0.606, 95% CI = 0.376–0.975, <italic>p</italic> = 0.039).</p><p><bold>Conclusion:</bold> Our study showed that genetic variants in <italic>TLRs</italic> were associated with risk of COPD. The rs3775291 and rs4696480 may act as a potential biomarker for predicting the risk of COPD in Chinese population.</p>