AUTHOR=Lei Lei , Tan Liao , Sui Long 

TITLE=A novel cuproptosis-related gene signature for predicting prognosis in cervical cancer

JOURNAL=Frontiers in Genetics

VOLUME=Volume 13 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2022.957744

DOI=10.3389/fgene.2022.957744

ISSN=1664-8021

ABSTRACT=Purpose: Cuproptosis, a copper-induced cell death, can be a promising therapeutic target for refractory cancers. Hence, we conduct this research to explore the association between cuproptosis and prognosis in Cervical cancer (CC). 
Methods: For constructing a prognostic signature based on the cuproptosis-related genes from the TCGA database, a least absolute shrinkage and selection operator Cox regression was utilized. The GSE44001 cohort was utilized for validation. 
Results: Nine cuproptosis-related genes showed distinct expression in CC and normal samples in the TCGA-GTEx cohort. Two risk groups were identified based on a seven-gene signature. A significant decrease in overall survival was observed in the high-risk group (P < 0.001). The risk score (HR = 2.77, 95%CI = 1.58-4.86) was an autocephalous predictor with better predictive ability than the clinical stage. Functional analysis indicated that immune activities were suppressed in the high-risk group than in the low-risk group. Eleven candidate compounds targeting the signature were identified. 
Conclusions：The seven cuproptosis-related genes signature were construct to predict prognosis and propose a new therapeutic target for patients with CC.