AUTHOR=Kheriji Nadia , Dallali Hamza , Gouiza Ismail , Hechmi Meriem , Mahjoub Faten , Mrad Mehdi , Krir Asma , Soltani Manel , Trabelsi Hajer , Hamdi Walid , Bahlous Afef , Ben Ahmed Melika , Jamoussi Henda , Kefi Rym 

TITLE=Whole-exome sequencing reveals novel variants of monogenic diabetes in Tunisia: impact on diagnosis and healthcare management

JOURNAL=Frontiers in Genetics

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2023.1224284

DOI=10.3389/fgene.2023.1224284

ISSN=1664-8021

ABSTRACT=Idiopathic type 1 diabetes was also identified in one patient. Conclusion: In this study, we emphasized the importance of genetic screening for MD in patients with familial history of diabetes mainly among admixed and under-represented populations living in Low-and Middle-Income countries. An accurate diagnosis with molecular investigation of MD may improve the therapeutic choice for better management of patients and their families. Additional researche and rigorous investigations are required to better understand phyisiopathological mechanisms of MD and to implement efficient therapies that takes into account genomic context and other related factors.