Due to a production error, a formatting error was made. In Table 1, in the third line of the column “Sweat volume in µL” should be “11d” instead of “114”. The corrected table appears below.
TABLE 1
| Code | Age in years | Skin | Scalp hair | Eyebrows/- lashes | Eyes | Respiratory problems | Current dental status | Reported heat sensitivity/intolerance | Body areas reportedly capable of sweating | Sweat ducts per cm2 | Sweat volume in µL | Other |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P1a | 16 | Dry | Sparse, very light | Both sparse | Dry | Noa | 4 d.t. + 1 p.t. | Yes | None | 0 | 0 | Allergies |
| P1b | 16 | Unremarkable | Rather sparse, light | Both sparse | Unremarkable | No | 3 d.t. + 20 p.t. | Nob | All-over | 408 | 8 | Allergies |
| P2 | 17 | Dry, fissured | Sparse, light | Sparse/unremarkable | Mild photophobia | Noc | 9 d.t. + 10 p.t. | Yes | Hands, feet, genital area, bends of the elbows, hollows of the knees, armpits | 62d | 11d | Allergies, polythelia |
| P3 | 28 | Very dry | Very sparse, very light | Both very sparse | Photophobia | Recurrent sinusitis, nasal crusting | 2 d.t. + 0 p.t. | Yes | Feet | 0 | 0 | Bilateral athelia, asthenic habitus |
| P4 | 8 | Dry, neurodermatitis | Rather normal, light | Very sparse/sparse | Unremarkablee | Nof | 10 d.t. + n.a. | Yes (mild) | Armpits, back | 200 | 0 | Allergies |
| P5 | 3 | Dry, partly eczematous, aplasia cutis congenita (healed) | Sparse | Absent/sparse | Lacrimal duct stenosis | Nasal crusting | 6 d.t. + n.a. | Episodes of hyperthermia in early infancy | None | n.a. | 0 | Impaired weight gain, sleep apnoea in first months of life |
Phenotypic features.
Abbreviations: d.t., deciduous teeth; p.t., permanent teeth; n.a., not assessed.
Except for bronchitis and nasal crusting in infancy.
But in infancy.
Except for recurrent laryngitis and nasal crusting in infancy.
Assessed at the age of 6 years (Schneider et al., 2011).
Except for recurrent conjunctivitis in early infancy.
Except for recurrent nosebleeds in early infancy.
The publisher apologizes for this mistake. The original version of this article has been updated.
Summary
Keywords
X-linked hypohidrotic ectodermal dysplasia, Ectodysplasin A, variants of uncertain significance, in silico analysis, functional studies, serum EDA concentration, genotype-phenotype correlation
Citation
Frontiers Production Office (2023) Erratum: Functional and clinical analysis of five EDA variants associated with ectodermal dysplasia but with a hard-to-predict significance. Front. Genet. 14:1281631. doi: 10.3389/fgene.2023.1281631
Received
22 August 2023
Accepted
22 August 2023
Published
31 August 2023
Approved by
Frontiers Editorial Office, Frontiers Media SA, Switzerland
Volume
14 - 2023
Updates
Copyright
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