AUTHOR=Cui Kai , Song Na , Fan Yanwu , Zeng Liqun , Shi Pingyu , Wang Ziwei , Su Wei , Wang Haijun 

TITLE=A two-sample Mendelian randomization analysis: causal association between chemokines and pan-carcinoma

JOURNAL=Frontiers in Genetics

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2023.1285274

DOI=10.3389/fgene.2023.1285274

ISSN=1664-8021

ABSTRACT=According to the 2020 data from the World Health Organization (WHO), cancers stand as one of the foremost contributors to global mortality. Revealing novel cancer risk factors and protective factors is of paramount importance in the prevention of disease occurrence. Studies on the relationship between chemokines and cancer are ongoing; however, due to the coordination of multiple potential mechanisms, the specific causal association remains unclear.Methods: We performed a bidirectional Mendelian randomization analysis to explore the causal association between serum chemokines and pan-carcinoma. All data is from the GWAS catalog and IEU Open GWAS database. The inverse variance weighting (IVW) method is primarily employed for assessing the statistical significance of the findings. In addition, the significance threshold after the multiple hypothesis test (Bonferroni) was 0.0013, and the evidence of a potential association was considered if the p-value < 0.05, but remained greater than Bonferroni's threshold.The results indicate that CCL1 (odds ratio, OR = 1.18), CCL2 (OR = 1.04),