AUTHOR=Ndiaye Rokhaya , Diop Jean Pascal Demba , Dem Ahmadou , Dieye Alioune 

TITLE=Genetic contribution of breast cancer genes in women of black African origin

JOURNAL=Frontiers in Genetics

VOLUME=Volume 14 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2023.1302645

DOI=10.3389/fgene.2023.1302645

ISSN=1664-8021

ABSTRACT=Breast cancer (BC) is an increasing public health issue worldwide. BC incidence and mortality rates are rising in transitioning countries in Africa, with the most rapid increase occurring in Sub-Saharan Africa (SSA). Female BC represents 25.8% of all cancer diagnosis in SSA. Early age at onset, high grade and triple negative tumors are hallmarks of BC in this region, associated with germline pathogenic variants in susceptibility genes. While several genes have been associated with genetic predisposition (BRCA1