AUTHOR=Ijaz Aqsa , Anwar Zunaira , Ali Ahmad , Ditta Allah , Shani Muhammad Yousaf , Haidar Sajjad , Wang Boahua , Fang Liu , Khan Sana Muhy-Ud-Din , Khan Muhammad Kashif Riaz TITLE=Unraveling the genetic and molecular basis of heat stress in cotton JOURNAL=Frontiers in Genetics VOLUME=Volume 15 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2024.1296622 DOI=10.3389/fgene.2024.1296622 ISSN=1664-8021 ABSTRACT=Human activities and climate change have resulted in frequent and intense weather fluctuations, leading to diverse abiotic stresses on crops which hampers greatly their metabolic activities. Heat stress, a prevalent abiotic factor, significantly influences impacts cotton cropsplant biological activities, resulting in reducing yield and production. To advance cotton breeding, wWe must deepen our understanding of how crops plants respond to heat stress across various dimensions, encompassing genes, RNAs, proteins, metabolites for effective cotton breeding, and phenotypes..To attain a more thorough understanding, employing mMulti-omics methods, primarily genomics, transcriptomics, proteomics, metabolomics, and phenomics, proves instrumental in studying cotton's responses to abiotic stresses. Integrating genomics, transcriptomics, proteomics, and metabolomic information poses a key challengeis imperative for functional genomics and systems biology in advancing our better understanding of cellular biologyregarding genetics and molecular basis of heat tolerance in cotton. The current review explores fundamental omics techniques, covering genomics, transcriptomics, proteomics, and metabolomics, to highlight the progress made in cotton omics research.