AUTHOR=Loktionov Alexey Valerevich , Kobzeva Ksenia Andreevna , Karpenko Andrey Romanovich , Sergeeva Vera Alexeevna , Orlov Yuriy Lvovich , Bushueva Olga Yurievna 

TITLE=GWAS-significant loci and severe COVID-19: analysis of associations, link with thromboinflammation syndrome, gene-gene, and gene-environmental interactions

JOURNAL=Frontiers in Genetics

VOLUME=Volume 15 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2024.1434681

DOI=10.3389/fgene.2024.1434681

ISSN=1664-8021

ABSTRACT=The aim of this study was to replicate associations of GWAS-significant loci with severe COVID-19 in the population of Central Russia, to investigate associations of the SNPs with thromboinflammation parameters, to analyze gene-gene and gene-environmental interactions.Materials and methods: DNA samples from 798 unrelated Caucasian subjects from Central Russia (199 hospitalized COVID-19 patients and 599 controls with a mild or asymptomatic course of COVID-19) were genotyped using probe-based PCR for 10 GWAS-significant SNPs: rs143334143