AUTHOR=You Hongjie , Zhang Hui , Jin Xiaofeng , Yan Zejun TITLE=Dysregulation of ubiquitination modification in renal cell carcinoma JOURNAL=Frontiers in Genetics VOLUME=Volume 15 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2024.1453191 DOI=10.3389/fgene.2024.1453191 ISSN=1664-8021 ABSTRACT=Renal cell carcinoma (RCC) is a malignant tumor of the renal tubular epithelial cells with a relatively high incidence rate worldwide. A large number of studies have indicated that dysregulation of the ubiquitination, including ubiquitination and dysregulation, is associated with the occurrence and development of RCC. This review focuses on several abnormal signaling pathways caused by E3 ligases and deubiquitinases. Additionally, we discuss research progress in RCC treatment by targeting key enzymes related to ubiquitination modifications.