AUTHOR=Jiwani Tayyaba , Akinwumi Adjua , Cheé-Santiago Jocelyn , Egorova Yulia , Frassetto Gabriel , di Lazzaro Filho Ricardo , Lopes-Cendes Iscia , Okumura Mercedes , Alonso Pavón José Antonio , Popejoy Alice B. , Skinner David , Wade Peter , Wienroth Matthias , Schwartz-Marin Ernesto , Naslavsky Michel Satya 

TITLE=Conceptualizing the public good for genomics in the global South: a cross-disciplinary roundtable dialogue

JOURNAL=Frontiers in Genetics

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2025.1523396

DOI=10.3389/fgene.2025.1523396

ISSN=1664-8021

ABSTRACT=Since the Human Genome Project, initiatives to genetically sequence and profile populations around the world have expanded rapidly. The rationales guiding this expansion are diverse: on the one hand, the concentration of genetic technologies in the global North threatens to widen the yawning gaps in healthcare available in advanced versus developing nations. On the other, more ‘genetic diversity’ in global databases can reveal new points of genetic variation associated with health or disease. This promises to pave the way to a more personalized medicine of the future—more powerful and prosperous, with tailored prevention regimens and genetic treatments targeted to every individual’s specific genetic vulnerabilities. These rationales are advanced to claim a public good case for genomics. However, the expansion of genomics to underserved populations in the global South has provoked many sociopolitical and ethical challenges. Critics have pointed to the inevitable entanglement of genomics with private commercial interests. These concerns are overlaid on deeper anxieties stemming from global asymmetries in scientific and technological power, and historical patterns of value extraction from colonized and marginalized populations. How then do we disentangle the public good? How do we build a genomics science that is just and equitable for the vast majority of the world? This conversation convenes leading genomics practitioners and critical science studies scholars to address these questions. We draw on an ongoing transdisciplinary dialogue, integrating the natural and social sciences, and bring together perspectives and scholars from the global North and South. Our aim is to cultivate a more holistic and grounded engagement with the scientific and political challenges we face, to truly understand the requirements of a genomics that centers the question of justice.