Frontiers in Genetics

Original Research

Published on 25 Nov 2025

Mechanistic study of TFE3 breakage in TFE3-rearranged renal cell carcinoma: the perspective of non-canonical DNA structures and their stability

in Cancer Genetics and Oncogenomics

Xiaopo Zhang
Qinshuang Dang
Xinghe Pan
Zhenggen Deng
Yanhao Xu
Weidong Gan
Hongqian Guo

Frontiers in Genetics

doi 10.3389/fgene.2025.1694739

1,320 views

Original Research

Published on 25 Nov 2025

Revealing the key modules and potential prognostic markers of gastric cancer transformation based on weighted gene co-expression networks

in Cancer Genetics and Oncogenomics

Heng Li
Wen Li
Zhen Yang
Haiyu Liu
Xiaoping Zhang
Yufeng Zhao
Hao Gu

Frontiers in Genetics

doi 10.3389/fgene.2025.1613682

1,674 views

Original Research

Published on 25 Nov 2025

Genomic analysis reveals genetic diversity and selection signatures of the Yantai Black pig during domestication and breeding

in Evolutionary and Population Genetics

Ming Qin
Cai Ma
Mingzhi Liang
Yuxin Zhang
Zengguang Wang
Jingyu Wang
Guodong Li
Yufen Sha
Peng Jin
Lingling Ju

Frontiers in Genetics

doi 10.3389/fgene.2025.1730668

1,454 views

Correction

Published on 24 Nov 2025

Correction: Non-coding RNAs in heart failure: epigenetic regulatory mechanisms and therapeutic potential

in RNA

Yubo Ren
Bomeng Zhao
Luo Lv
Jingyuan Yang
Xiangting Nan
Bao Li
Bin Yang

Frontiers in Genetics

doi 10.3389/fgene.2025.1746339

897 views
1 citation

Editorial

Published on 24 Nov 2025

Editorial: Responses and adaptation of plants to abiotic stress: genetics, evolution and molecular insights

in Genetics and Genomics of Plants and Plant-Associated Organisms

Yang Tao
Xilan Yang
Zhiqiang Wang

Frontiers in Genetics

doi 10.3389/fgene.2025.1729869

1,305 views

Original Research

Published on 24 Nov 2025

Application of trio-based whole-exome sequencing in fetal ultrasound anomalies: a single-center retrospective study of 454 cases

in Genetics of Common and Rare Diseases

Dongyi Yu
Dairong Feng
Jiangbo Qu
Lei Nie
Qian Liu
Lu Gao
Wenzhen An
Na Liu
Yuying Fang

Frontiers in Genetics

doi 10.3389/fgene.2025.1662801

1,432 views

Review

Published on 24 Nov 2025

Circular RNAs at the crossroads of acute pancreatitis: bridging molecular mechanisms to diagnostic and therapeutic innovations

in RNA

Jing Chen
XiaoLing Chen
Fei He

Frontiers in Genetics

doi 10.3389/fgene.2025.1650363

1,203 views

Editorial

Published on 24 Nov 2025

Editorial: Unraveling the mysteries of aging and the brain: advancements in understanding neurodegenerative diseases and dementia

in Genetics of Aging

Victoria Campos-Peña

Frontiers in Genetics

doi 10.3389/fgene.2025.1745907

1,228 views

Mini Review

Published on 24 Nov 2025

Ecuador genetic mosaic: biological and adaptive variations across Mestizos, Native Amerindians, and Afro-Ecuadorians. Implications for public health and precision medicine

in Evolutionary and Population Genetics

Fabricio González-Andrade

Frontiers in Genetics

doi 10.3389/fgene.2025.1699402

1,870 views

Case Report

Published on 21 Nov 2025

Case Report: Mild BRIC-like cholestasis despite a gross USP53 deletion—novel findings and literature review

in Genetics of Common and Rare Diseases

Ekaterina Nuzhnaya
Tatiana Cherevatova
Ekaterina Lotnik
Aleksandra Shagiazdanova
Zhanna Markova
Ekaterina Filimonova
Olga Parshina
Anastasiia Buianova
Anastasia Bobreshova
Andrey Marakhonov

Frontiers in Genetics

doi 10.3389/fgene.2025.1670664

1,367 views

Original Research

Published on 21 Nov 2025

Transcriptome-wide m6A landscape across diverse porcine tissues revealed by nanopore direct RNA sequencing

in Livestock Genomics

Yaya Liao
Zifeng Ding
Xiaoyun Chen
Chao Yin
Bin Yang
Qiang Yang
Yuyun Xing

Frontiers in Genetics

doi 10.3389/fgene.2025.1725608

1,653 views

Original Research

Published on 20 Nov 2025

Benign mosaic chromosomal structural variants across generations: evidence for a developmental correction mechanism from clinical and computational models

in Human and Medical Genomics

Jiayu Ruan
Qinhao Song
Yue Hu
Xiaodan Liu
Suping Li
Jianjun Zhu
Li Yang

Frontiers in Genetics

doi 10.3389/fgene.2025.1710280

1,303 views
1 citation

Methods

Published on 20 Nov 2025

A network-based discovery of prognostic markers in recurrent IDH wild-type gliomas

in Computational Genomics

Yang Liu
Jason Huse
Kasthuri Kannan

Frontiers in Genetics

doi 10.3389/fgene.2025.1672015

1,485 views

Review

Published on 20 Nov 2025

Bioinformatics identification of key genes and therapeutic targets for exercise intervention in polycystic ovary syndrome

in Computational Genomics

Xiaodie Yang
Hong Yang
Dongyi Shen
Qiang Zhang
Chan Zhu

Frontiers in Genetics

doi 10.3389/fgene.2025.1634588

1,582 views

Opinion

Published on 20 Nov 2025

Why all MODY variants in transcription factor genes are dominantly inherited

in Genetics of Common and Rare Diseases

Roman Zug

Frontiers in Genetics

doi 10.3389/fgene.2025.1690468

1,444 views

Original Research

Published on 20 Nov 2025

Five novel EP300 variants expand the genetic and phenotypic spectrum of Rubinstein–Taybi syndrome type 2 in Chinese patients

in Neurogenomics

Qiang Zhang
Qi Yang
Xunzhao Zhou
Zailong Qin
Jingsi Luo

Frontiers in Genetics

doi 10.3389/fgene.2025.1690693

1,451 views

Original Research

Published on 20 Nov 2025

SHMT2 modulates the transcriptome and metabolism profiles to promote the tumor phenotypes of bladder cancer HT-1376 cells

in Cancer Genetics and Oncogenomics

Xiaobo Guo
Gang Li

Frontiers in Genetics

doi 10.3389/fgene.2025.1694089

1,495 views

Original Research

Published on 19 Nov 2025

Potential diagnostic markers and therapeutic targets for obstructive sleep apnea with comorbid depression based on bioinformatics analysis

in Computational Genomics

Yinfei Lu
Zao Tang
Xiangyu Zhou
Wanting Lin
Xiao Guo

Frontiers in Genetics

doi 10.3389/fgene.2025.1655000

1,644 views

Original Research

Published on 19 Nov 2025

FTO rs9939609 and rs17817449 polymorphisms contribute to metabolic syndrome risk by increasing triglyceride and glucose levels

in Genetics of Common and Rare Diseases

Yongyan Song
Ting Wang
Mi Su
Xue Wang
Youjin Zhang
Jia Pan
Yunhan Wang
Jin Yang

Frontiers in Genetics

doi 10.3389/fgene.2025.1659460

1,398 views

Review

Published on 19 Nov 2025

Single-cell sequencing in molecular diagnostics: Transformative yet untapped potential

in Genomic Assay Technology

Duaa Elshiekh
Nour Farchoukh
Reema El Hassan
Sara Al-Marzooqi
Waad Rashed Aldosari
Haissam Abou-Saleh
Amal Al-Haidose
Hatem Zayed
Atiyeh M. Abdallah

Frontiers in Genetics

doi 10.3389/fgene.2025.1621081

2,404 views

Case Report

Published on 18 Nov 2025

MAPT mutation-induced behavioral variant frontotemporal dementia in an Asian patient: a multimodal biomarker case report resolving diagnostic challenges with Alzheimer’s disease

in Genetics of Common and Rare Diseases

Yan Zhang
Siwei Chen
Guiying Yan
Zhifei Zhang
Amina
Ting Wang
Shuang Wang
Chen Zhang
Yong’an Sun

Frontiers in Genetics

doi 10.3389/fgene.2025.1645068

1,732 views

Original Research

Published on 18 Nov 2025

PANoptosis-related gene clusters and prognostic risk model in clear cell renal cell carcinoma

in Cancer Genetics and Oncogenomics

Qiyue Zhao
Huadong Xie
Chaofu Li
Yanxiang Xiong
Yongyi Fan
Yuanbi Huang
Yi Zhan
Siping Zeng

Frontiers in Genetics

doi 10.3389/fgene.2025.1605078

1,988 views

Original Research

Published on 17 Nov 2025

Phenotype and genetic variation analysis of primary congenital lymphedema caused by FLT4 gene mutations in a fetus

in Genetics of Common and Rare Diseases

Shanshan Zhai
Limin Yuan
Jing Li
Ling Liu
Lulu Hu
Yanjie Ban
Xuewen Yang
Jie Yang
Xuezhe Ouyang
Nana Huang

Frontiers in Genetics

doi 10.3389/fgene.2025.1700635

1,280 views

Original Research

Published on 17 Nov 2025

Genetic evolution of parental populations and construction of core germplasm populations in qinghai spruce seed orchard based on SLAF-seq technology

in Evolutionary and Population Genetics

Hu Zhao
Erwen Xu
Dong Lv
Wei Li
Xingpeng Zhao
Xin Jia
Hao Yuan
Rong Zhou

Frontiers in Genetics

doi 10.3389/fgene.2025.1712106

1,528 views

16,584 articles

articles

Mechanistic study of TFE3 breakage in TFE3-rearranged renal cell carcinoma: the perspective of non-canonical DNA structures and their stability

Revealing the key modules and potential prognostic markers of gastric cancer transformation based on weighted gene co-expression networks

Genomic analysis reveals genetic diversity and selection signatures of the Yantai Black pig during domestication and breeding

Correction: Non-coding RNAs in heart failure: epigenetic regulatory mechanisms and therapeutic potential

Editorial: Responses and adaptation of plants to abiotic stress: genetics, evolution and molecular insights

Application of trio-based whole-exome sequencing in fetal ultrasound anomalies: a single-center retrospective study of 454 cases

Circular RNAs at the crossroads of acute pancreatitis: bridging molecular mechanisms to diagnostic and therapeutic innovations

Editorial: Unraveling the mysteries of aging and the brain: advancements in understanding neurodegenerative diseases and dementia

Ecuador genetic mosaic: biological and adaptive variations across Mestizos, Native Amerindians, and Afro-Ecuadorians. Implications for public health and precision medicine

Case Report: Mild BRIC-like cholestasis despite a gross USP53 deletion—novel findings and literature review

Transcriptome-wide m6A landscape across diverse porcine tissues revealed by nanopore direct RNA sequencing

Benign mosaic chromosomal structural variants across generations: evidence for a developmental correction mechanism from clinical and computational models

A network-based discovery of prognostic markers in recurrent IDH wild-type gliomas

Bioinformatics identification of key genes and therapeutic targets for exercise intervention in polycystic ovary syndrome

Why all MODY variants in transcription factor genes are dominantly inherited

Five novel EP300 variants expand the genetic and phenotypic spectrum of Rubinstein–Taybi syndrome type 2 in Chinese patients

SHMT2 modulates the transcriptome and metabolism profiles to promote the tumor phenotypes of bladder cancer HT-1376 cells

Potential diagnostic markers and therapeutic targets for obstructive sleep apnea with comorbid depression based on bioinformatics analysis

FTO rs9939609 and rs17817449 polymorphisms contribute to metabolic syndrome risk by increasing triglyceride and glucose levels

Single-cell sequencing in molecular diagnostics: Transformative yet untapped potential

MAPT mutation-induced behavioral variant frontotemporal dementia in an Asian patient: a multimodal biomarker case report resolving diagnostic challenges with Alzheimer’s disease

PANoptosis-related gene clusters and prognostic risk model in clear cell renal cell carcinoma

Phenotype and genetic variation analysis of primary congenital lymphedema caused by FLT4 gene mutations in a fetus

Genetic evolution of parental populations and construction of core germplasm populations in qinghai spruce seed orchard based on SLAF-seq technology