Frontiers in Genetics | New and Recent Articles https://www.frontiersin.org/journals/genetics RSS Feed for Frontiers in Genetics | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-04-25T14:37:47.552+00:00 60 https://www.frontiersin.org/articles/10.3389/fgene.2026.1779551 https://www.frontiersin.org/articles/10.3389/fgene.2026.1779551 <![CDATA[Clinical outcomes of preimplantation genetic testing for structural rearrangements in couples with chromosomal inversions: a retrospective analysis]]> 2026-04-24T00:00:00Z Original Research Yutong LiYuezhi KeqieCuiting PengHan ChenJun RenHong YangZhushu LiuWei FanShan LuoXuemei ZhangTing HuShanling LiuXinlian ChenFan Zhou 0.05); however, a statistically significant difference was observed between the PGT-SR group and each of the other three groups (P < 0.001). The aneuploidy rate in couples with female inversion was significantly higher than that in couples with male inversion (P = 0.046). Meanwhile, the proportion of aneuploid blastocysts associated with rearrangement was significantly higher in pericentric (38.94%) compared to paracentric inversions (23.60%) (P = 0.022). With the inverted fragment size increased, the proportion of aneuploid blastocysts associated with rearranged chromosomes increased accordingly and exhibited a linear trend (P < 0.05). In conclusion, the overall euploid rate of blastocysts in couples with chromosomal inversion showed no statistically significant difference compared to those with normal karyotype and chromosomal polymorphic variation; however, the carrier gender and the size of the inverted fragment are influencing factors for the abnormality rate associated with homologous rearranged chromosomes. Genetic counseling is strongly recommended for couples carrying chromosomal inversions.]]> https://www.frontiersin.org/articles/10.3389/fgene.2026.1800699 https://www.frontiersin.org/articles/10.3389/fgene.2026.1800699 <![CDATA[Development and research trends of stay-green biology in legumes: a bibliometric and visual analysis over three decades]]> 2026-04-24T00:00:00Z Systematic Review Shubh Pravat Singh YadavUpama AdhikariJames R. MyersLyle T. Wallace https://www.frontiersin.org/articles/10.3389/fgene.2026.1795752 https://www.frontiersin.org/articles/10.3389/fgene.2026.1795752 <![CDATA[Leveraging Hamiltonian neural flow for robust single-cell multi-omics integration: application to Alzheimer’s disease]]> 2026-04-24T00:00:00Z Original Research Ziheng HuangWei KongShuaiqun Wang https://www.frontiersin.org/articles/10.3389/fgene.2026.1803717 https://www.frontiersin.org/articles/10.3389/fgene.2026.1803717 <![CDATA[Clinical variant interpretation comparing two saturation genome editing-based functional studies for BRCA2]]> 2026-04-24T00:00:00Z Original Research Ju Hyeon ShinKyung Sun ParkYoung-gon KimMi-Ae JangJa-Hyun JangJong-Won Kim https://www.frontiersin.org/articles/10.3389/fgene.2026.1697926 https://www.frontiersin.org/articles/10.3389/fgene.2026.1697926 <![CDATA[Causal effects of maternal BMI on pregnancy outcomes: a Mendelian randomisation study investigating the mediating role of blood counts]]> 2026-04-24T00:00:00Z Original Research Christopher FlatleyGeng WangAlesha HattonKym-Mai NguyenLiang-Dar HwangNicole M. Warrington https://www.frontiersin.org/articles/10.3389/fgene.2026.1791446 https://www.frontiersin.org/articles/10.3389/fgene.2026.1791446 <![CDATA[Sex-specific variations in subgingival microbiome of elderly patients with moderate periodontitis: an exploratory study]]> 2026-04-24T00:00:00Z Original Research Ya-Qiong ZhaoBi-Fen KuangMarie Aimee DusengeQiong LiuFeng-Yi ZhangYing-Hui Zhou https://www.frontiersin.org/articles/10.3389/fgene.2026.1752017 https://www.frontiersin.org/articles/10.3389/fgene.2026.1752017 <![CDATA[Charting the immune terrain: a novel risk model for thyroid cancer prognosis]]> 2026-04-23T00:00:00Z Original Research Qi QiXiaoyan CaiQiang Lv https://www.frontiersin.org/articles/10.3389/fgene.2026.1810737 https://www.frontiersin.org/articles/10.3389/fgene.2026.1810737 <![CDATA[Decoding thalassemia and sickle cell disease: advances in molecular technologies for comprehensive variant detection]]> 2026-04-23T00:00:00Z Review Emelie FoordDarius SairafiMonika BergSofia WesterlingToheeb AdigunMehmet UzunelThessalia PapasavvaMichael Uhlin https://www.frontiersin.org/articles/10.3389/fgene.2026.1771872 https://www.frontiersin.org/articles/10.3389/fgene.2026.1771872 <![CDATA[The role of pluripotency regulators in triple-negative breast cancer immune response]]> 2026-04-23T00:00:00Z Review Carolina López-SantanaFabio Mendez-RiveraDavid A. Bernal-Estévez https://www.frontiersin.org/articles/10.3389/fgene.2026.1792974 https://www.frontiersin.org/articles/10.3389/fgene.2026.1792974 <![CDATA[Prevalence of GSTM1 and GSTT1 null polymorphisms in an admixed healthy Venezuelan population: implications for pharmacogenetic baselines]]> 2026-04-23T00:00:00Z Original Research Mercedes Fernández-MestreEva Salazar-AlcaláJuan Bautista De SanctisDolores MorenoJenny Valentina GarmendiaOriana Regalado-GutiérrezMaría Johanna Peña https://www.frontiersin.org/articles/10.3389/fgene.2026.1808090 https://www.frontiersin.org/articles/10.3389/fgene.2026.1808090 <![CDATA[Genomic basis of adaptation to cardiac glycosides in three insect orders]]> 2026-04-22T00:00:00Z Original Research Kangli ZhuChengqi ZhuYing Zhen https://www.frontiersin.org/articles/10.3389/fgene.2026.1792347 https://www.frontiersin.org/articles/10.3389/fgene.2026.1792347 <![CDATA[Framework for assessing genetic variation in livestock using demographic, pedigree, and genomic measures]]> 2026-04-22T00:00:00Z Review Gábor MészárosIno CurikDominique OuedraogoJack WindigGregoire LeroyYuri Tani UtsunomiyaPamela BurgerLicia ColliChang XuPaul BoettcherChristian LooftJohann Soelkner https://www.frontiersin.org/articles/10.3389/fgene.2026.1761836 https://www.frontiersin.org/articles/10.3389/fgene.2026.1761836 <![CDATA[Polydactyly and syndactyly in a Chinese family with Floating-Harbor syndrome: an expansion of the clinical phenotype]]> 2026-04-22T00:00:00Z Original Research Junxiang TangYanhong CaoDaoqi HuangChaohong WangXiaohua JiangJiansheng Zhu T (p.Arg2444Ter) mutation in both affected individuals. The proband also harbored compound heterozygous mutations in MMACHC (c.609G>A/p.Trp203Ter and c.565C>T/p.Arg189Cys), potentially explaining some extra-skeletal symptoms. In summary, this study describes the first case of FLHS concurrently presenting with both polydactyly and syndactyly. Our work broadens the known phenotypic range of this rare syndrome.]]> https://www.frontiersin.org/articles/10.3389/fgene.2026.1775858 https://www.frontiersin.org/articles/10.3389/fgene.2026.1775858 <![CDATA[Integrated metabolomics and bioactivity analysis of Cynoglossum lanceolatum root extract as a natural inducer of resistance to rice bacterial blight]]> 2026-04-22T00:00:00Z Original Research Aadil MansooriMadan MohanSubha Narayan DasRakesh KumarAnirudh Kumar https://www.frontiersin.org/articles/10.3389/fgene.2026.1770769 https://www.frontiersin.org/articles/10.3389/fgene.2026.1770769 <![CDATA[Nanopore-m6A-finder, a novel m6A site caller for Nanopore DRS data]]> 2026-04-22T00:00:00Z Original Research Yuening YangLiqun YuLi MoChanghai QiWei SongHua Jin 0.80). Comparing with canonical m6A detection methods, it recovered 20% of meRIP-seq-defined m6A sites in yeast, and 27% of our HEK293 site prediction overlapped with miCLIP calls. Although single-base overlap with existing DRS-based tools of EpiNano and mAFiA was limited, 73% of our identified m6A-containing genes were validated by at least one of them. Benchmarking our method with GLORI v2.0 revealed concordance of 28% at a site level and 85% at a gene level, as well as a mild correlation on m6A level estimations. Notably, NP-mFinder achieved 93% precision in detecting m6A within the “AAAAA” sequence context in the mRNA exonic region of HEK293T DRS data when compared to high-confidence m6A site annotation in GLORI v2.0, demonstrating the good performance of our method in the region possessing a stretch of continuous A-sequences. Moreover, our method predicted that m6A might exist in the human HEK293 poly(A) region, suggesting a possibly conserved phenomenon of a modified poly(A) tail beyond the previously reported T. brucei variant surface glycoprotein (VSG) transcripts. Together, these results established NP-mFinder as a robust and versatile tool for transcriptome-wide m6A profiling with DRS data at single-read resolution.]]> https://www.frontiersin.org/articles/10.3389/fgene.2026.1603788 https://www.frontiersin.org/articles/10.3389/fgene.2026.1603788 <![CDATA[A novel prognostic model for ovarian cancer: construction, validation, and therapeutic insights]]> 2026-04-22T00:00:00Z Original Research Tingting YuMingyang GaoYuexin YuBolun Wang https://www.frontiersin.org/articles/10.3389/fgene.2026.1845666 https://www.frontiersin.org/articles/10.3389/fgene.2026.1845666 <![CDATA[Correction: BRMDA: prediction model for potential microbe-drug associations based on bilinear attention networks and random forest]]> 2026-04-21T00:00:00Z Correction Ge YuFang ChenHui ChenShichang TangMingmin LiangXianzhi LiuBin ZengLei Wang https://www.frontiersin.org/articles/10.3389/fgene.2026.1846361 https://www.frontiersin.org/articles/10.3389/fgene.2026.1846361 <![CDATA[Editorial: Genetic underpinnings of Alzheimer’s and Parkinson’s: insights and innovations]]> 2026-04-21T00:00:00Z Editorial Roberta MarongiuDennis CordatoAllison B. Reiss https://www.frontiersin.org/articles/10.3389/fgene.2026.1794156 https://www.frontiersin.org/articles/10.3389/fgene.2026.1794156 <![CDATA[Network-based multi-omics approaches to identify molecular signatures associated with pregnancy status in beef heifers]]> 2026-04-20T00:00:00Z Original Research T. Cody BrownPriyanka BanerjeePaul W. DyceShollie FalkenbergSoren P. RodningWellison J. S. Diniz https://www.frontiersin.org/articles/10.3389/fgene.2026.1799301 https://www.frontiersin.org/articles/10.3389/fgene.2026.1799301 <![CDATA[Sez6l promotes neuropathic pain via Wnt5a/Ca2+ pathways in dorsal root ganglion]]> 2026-04-20T00:00:00Z Original Research Limin HuJunjie Chen