Frontiers in Genetics | Immunogenetics section | New and Recent Articles https://www.frontiersin.org/journals/genetics/sections/immunogenetics RSS Feed for Immunogenetics section in the Frontiers in Genetics journal | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-05-02T04:34:11.316+00:00 60 https://www.frontiersin.org/articles/10.3389/fgene.2026.1771872 https://www.frontiersin.org/articles/10.3389/fgene.2026.1771872 <![CDATA[The role of pluripotency regulators in triple-negative breast cancer immune response]]> 2026-04-23T00:00:00Z Review Carolina López-SantanaFabio Mendez-RiveraDavid A. Bernal-Estévez https://www.frontiersin.org/articles/10.3389/fgene.2026.1786514 https://www.frontiersin.org/articles/10.3389/fgene.2026.1786514 <![CDATA[Identification of a novel HLA-G allele, HLA-G*01:66, using PolyseqOne and oxford nanopore sequencing]]> 2026-03-04T00:00:00Z Brief Research Report Ran LiLiyan SunSiqi Cai https://www.frontiersin.org/articles/10.3389/fgene.2026.1775026 https://www.frontiersin.org/articles/10.3389/fgene.2026.1775026 <![CDATA[Integrative biology shows DPP4 affects inflammatory response to eclampsia and cell model growth via p65/NLRP3/ASC/Caspase-1 pathway]]> 2026-03-04T00:00:00Z Original Research Zhimin BianLi HaoRongjuan YangJianghui Sun https://www.frontiersin.org/articles/10.3389/fgene.2025.1745482 https://www.frontiersin.org/articles/10.3389/fgene.2025.1745482 <![CDATA[KIR AA individuals possess strong inhibitory KIR alleles alongside HLA ligands that are protective against leukemia in the Chinese population]]> 2026-02-05T00:00:00Z Original Research Zhihui DengJianxin ZhenYunan LiShuang LiangManru ZhangSiqi CaiRenhui JiangZhichao YangQiong YuJinyong WangJie Liu https://www.frontiersin.org/articles/10.3389/fgene.2025.1771063 https://www.frontiersin.org/articles/10.3389/fgene.2025.1771063 <![CDATA[Editorial: Genetics of pediatric immune-mediated diseases]]> 2026-01-19T00:00:00Z Editorial Sara MantiBeatriz Elena Marciano https://www.frontiersin.org/articles/10.3389/fgene.2025.1720056 https://www.frontiersin.org/articles/10.3389/fgene.2025.1720056 <![CDATA[Impacts of rs7528684 (−169T/C) on FCRL3, FOXP3, and IL-35 gene expressions and IgG-RF correlation: insights into the pathogenesis of rheumatoid arthritis]]> 2026-01-02T00:00:00Z Original Research S. Mohamed MuzammilS. Asha Devi https://www.frontiersin.org/articles/10.3389/fgene.2025.1722527 https://www.frontiersin.org/articles/10.3389/fgene.2025.1722527 <![CDATA[Transcriptomic profiling of human endothelial cells infected with venezuelan equine encephalitis virus reveals NRF2 driven host reprogramming mediated by omaveloxolone treatment]]> 2025-12-18T00:00:00Z Original Research Mostafa RezapourLorreta A. OpokuStephanie V. TrefryAbbas AliliMaame KonaduMaria Galarza DionisioMetin Nafi GurcanAarthi Narayanan https://www.frontiersin.org/articles/10.3389/fgene.2025.1661511 https://www.frontiersin.org/articles/10.3389/fgene.2025.1661511 <![CDATA[Emerging roles of natural killer cell ligands—HLA-E, HLA-F, HLA-G, MICA, and MICB—in in vitro fertilization outcomes]]> 2025-11-13T00:00:00Z Review Itta Krishna ChaaithanyaRaja Rajalingam https://www.frontiersin.org/articles/10.3389/fgene.2025.1641956 https://www.frontiersin.org/articles/10.3389/fgene.2025.1641956 <![CDATA[A novel de novo IL2RG nonsense mutation in a pediatric patient with X-linked severe combined immunodeficiency]]> 2025-10-07T00:00:00Z Original Research Lin WangAiyan RenYuanyuan HeLu WangSixi WangXin XieMei TanYan ChenPei HuangZuochen Du A, p.Cys72*), and to contextualize these findings through a review of reported cases of X-SCID associated with Talaromyces marneffei (T. marneffei) infection, highlighting the immunological and diagnostic relevance of the mutation.MethodsThe clinical data of a child with X-SCID caused by an IL2RG mutation were retrospectively analyzed. Whole-exome sequencing and Sanger sequencing were used to identify the mutation, and flow cytometry was employed for immunophenotypic analysis to assess the impact of the mutation on immune function. A literature review was performed on reported cases of X-SCID associated with T. marneffei infection identified in PubMed and Scopus.ResultsThe patient was a 4-month-old male infant presenting with chronic diarrhea, recurrent fever, and anemia, with poor response to antibiotic treatment. Laboratory tests indicated T. marneffei infection, significantly reduced T lymphocytes and NK cells, and decreased levels of immunoglobulins (IgG, IgA, IgE). Genetic testing revealed a de novo hemizygous mutation in the IL2RG gene (NM_000206.3; exon2 c.216C > A, p.Cys72*), which has not been previously reported. Flow cytometric analysis showed a severe reduction in T lymphocytes, absence of CD8 + T cells, reduced NK cells, and a normal number of B lymphocytes. Six cases of IL2RG gene mutation combined with T. marneffei infection were identified in the literature, most showing fever, hepatosplenomegaly and respiratory tract infection.ConclusionThis case of X-SCID caused by a novel de novo IL2RG mutation expands the known mutation spectrum and highlights its immunological and diagnostic relevance. The review of reported cases of X-SCID with T. marneffei infection further clarifies genotype–phenotype correlations and supports improved recognition of such rare presentations.]]> https://www.frontiersin.org/articles/10.3389/fgene.2025.1686852 https://www.frontiersin.org/articles/10.3389/fgene.2025.1686852 <![CDATA[Editorial: Mitochondria in metabolic reprogramming and immune activation: the key gene and therapeutic target]]> 2025-09-01T00:00:00Z Editorial Yongzheng Guo https://www.frontiersin.org/articles/10.3389/fgene.2025.1628428 https://www.frontiersin.org/articles/10.3389/fgene.2025.1628428 <![CDATA[Genetic association between STAT4 and primary Sjögren’s syndrome in Han Chinese women]]> 2025-07-23T00:00:00Z Original Research Fangfang LiJunhui LuChao CenWanqiu ZhenJiaojiao ZhangShengming Wang https://www.frontiersin.org/articles/10.3389/fgene.2025.1619032 https://www.frontiersin.org/articles/10.3389/fgene.2025.1619032 <![CDATA[Editorial: Proficiency testing in histocompatibility and immunogenetics: current status and future perspectives]]> 2025-06-05T00:00:00Z Editorial Martin PetrekKelley M. K. Hitchman https://www.frontiersin.org/articles/10.3389/fgene.2025.1506862 https://www.frontiersin.org/articles/10.3389/fgene.2025.1506862 <![CDATA[Disentangling effects of the DR and DQ isomers encoded by the HLA class II haplotype DRB1*15:01/DQB1*06:02 to help establish the true risk allele for FVIII inhibitor development in Hemophilia A]]> 2025-04-09T00:00:00Z Brief Research Report Vincent P. DiegoBernadette W. LuuMarcio A. AlmeidaRaja RajalingamMarco HofmannJacob A. GalanEron G. ManusovJerry S. PowellLong V. DinhHenry MeadHuy HuynhAnne M. VerhagenJuan M. PeraltaPaul V. LehmannSatish KumarEli J. FineJoanne E. CurranHarald H. GoringMiguel A. EscobarSarah Williams-BlangeroEugene MaraskovskyJohn BlangeroTom E. Howard https://www.frontiersin.org/articles/10.3389/fgene.2025.1572987 https://www.frontiersin.org/articles/10.3389/fgene.2025.1572987 <![CDATA[Editorial: Novel applications of epitope biology to improve outcomes in transplantation]]> 2025-02-26T00:00:00Z Editorial James H. LanRobert LiwskiAlberto Cardoso Martins LimaSandra Tafulo https://www.frontiersin.org/articles/10.3389/fgene.2025.1505933 https://www.frontiersin.org/articles/10.3389/fgene.2025.1505933 <![CDATA[Vitamin A family suppresses periodontitis by restoring mitochondrial metabolic reprogramming in macrophages through JAK-STAT pathway]]> 2025-01-28T00:00:00Z Original Research Zishuo ChengShun HuangQiya TangDanlan ZhangLan Huang https://www.frontiersin.org/articles/10.3389/fgene.2024.1502832 https://www.frontiersin.org/articles/10.3389/fgene.2024.1502832 <![CDATA[Global deletion of the immune cell transcription factor, T-bet, alters gut microbiota and insulin sensitivity in mice]]> 2024-11-27T00:00:00Z Original Research E. StolarczykC. T. VongN. Garrido-MesaE. MarksD. Abdel-AzizQ. JuI. JacksonN. PowellG. M. LordJ. K. Howard https://www.frontiersin.org/articles/10.3389/fgene.2024.1449301 https://www.frontiersin.org/articles/10.3389/fgene.2024.1449301 <![CDATA[epiArt: a graphical HLA eplet amino acid repertoire translation reveals the need for an epitope driven revision of allele group nomenclature]]> 2024-10-16T00:00:00Z Original Research Ilias DoxiadisClaudia LehmannNils LachmannHenry Loeffler-Wirth https://www.frontiersin.org/articles/10.3389/fgene.2024.1442018 https://www.frontiersin.org/articles/10.3389/fgene.2024.1442018 <![CDATA[Improving long-term kidney allograft survival by rethinking HLA compatibility: from molecular matching to non-HLA genes]]> 2024-10-02T00:00:00Z Review Aprajita MattooIan S. JaffeBrendan KeatingRobert A. MontgomeryMassimo Mangiola https://www.frontiersin.org/articles/10.3389/fgene.2024.1436194 https://www.frontiersin.org/articles/10.3389/fgene.2024.1436194 <![CDATA[Allogeneic mesenchymal stromal cell therapy in kidney transplantation: should repeated human leukocyte antigen mismatches be avoided?]]> 2024-09-27T00:00:00Z Original Research Suzanne BezstarostiPauline ErpicumGianni MaggipintoGeertje J. DreyerMarlies E. J. ReindersSoufian MeziyerhDave L. RoelenJohan W. De FijterJesper KersLaurent WeekersYves BeguinFrançois JouretSebastiaan Heidt https://www.frontiersin.org/articles/10.3389/fgene.2024.1444554 https://www.frontiersin.org/articles/10.3389/fgene.2024.1444554 <![CDATA[Quantifying uncertainty of molecular mismatch introduced by mislabeled ancestry using haplotype-based HLA genotype imputation]]> 2024-09-25T00:00:00Z Original Research Benedict M. MaternEric SpieringsSelle BandstraAbeer MadboulyStefan SchaubEric T. WeimerMatthias Niemann