Frontiers in Genetics | RNA section | New and Recent Articles https://www.frontiersin.org/journals/genetics/sections/rna RSS Feed for RNA section in the Frontiers in Genetics journal | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-05-09T18:51:33.840+00:00 60 https://www.frontiersin.org/articles/10.3389/fgene.2026.1773468 https://www.frontiersin.org/articles/10.3389/fgene.2026.1773468 <![CDATA[Diverse roles of YTHDC1 in chromatin and blood cancers]]> 2026-05-08T00:00:00Z Review Baptiste PernonYacine BenchikhCyril FournierMaxime DelforgeBaptiste DumétierLaurent DelvaAmandine DurandCédric RossiLaurent MartinFabien GuidezAndré VerdelRomain AucagneMary B. Callanan https://www.frontiersin.org/articles/10.3389/fgene.2026.1825784 https://www.frontiersin.org/articles/10.3389/fgene.2026.1825784 <![CDATA[RUNX1-mediated repression of miR-24 promotes hepatic stellate cell activation and liver fibrosis by targeting the ALK4/Smad3 signaling pathway]]> 2026-04-30T00:00:00Z Original Research Zhijing WangMeiyi SongYingying ZhaoJing LiLu XiaFei WangChangqing Yang https://www.frontiersin.org/articles/10.3389/fgene.2026.1781941 https://www.frontiersin.org/articles/10.3389/fgene.2026.1781941 <![CDATA[Single cell and single nucleus RNA sequencing in liver tissues: applications and prospects in model and non-model organisms]]> 2026-04-28T00:00:00Z Review Xue FengYu FengSayed Haidar Abbas RazaYun MaHongyu Deng https://www.frontiersin.org/articles/10.3389/fgene.2026.1770769 https://www.frontiersin.org/articles/10.3389/fgene.2026.1770769 <![CDATA[Nanopore-m6A-finder, a novel m6A site caller for Nanopore DRS data]]> 2026-04-22T00:00:00Z Original Research Yuening YangLiqun YuLi MoChanghai QiWei SongHua Jin 0.80). Comparing with canonical m6A detection methods, it recovered 20% of meRIP-seq-defined m6A sites in yeast, and 27% of our HEK293 site prediction overlapped with miCLIP calls. Although single-base overlap with existing DRS-based tools of EpiNano and mAFiA was limited, 73% of our identified m6A-containing genes were validated by at least one of them. Benchmarking our method with GLORI v2.0 revealed concordance of 28% at a site level and 85% at a gene level, as well as a mild correlation on m6A level estimations. Notably, NP-mFinder achieved 93% precision in detecting m6A within the “AAAAA” sequence context in the mRNA exonic region of HEK293T DRS data when compared to high-confidence m6A site annotation in GLORI v2.0, demonstrating the good performance of our method in the region possessing a stretch of continuous A-sequences. Moreover, our method predicted that m6A might exist in the human HEK293 poly(A) region, suggesting a possibly conserved phenomenon of a modified poly(A) tail beyond the previously reported T. brucei variant surface glycoprotein (VSG) transcripts. Together, these results established NP-mFinder as a robust and versatile tool for transcriptome-wide m6A profiling with DRS data at single-read resolution.]]> https://www.frontiersin.org/articles/10.3389/fgene.2026.1813517 https://www.frontiersin.org/articles/10.3389/fgene.2026.1813517 <![CDATA[Brave new RNA world(s): from prebiotic chemistry to gene regulation and RNA technology]]> 2026-04-15T00:00:00Z Review Alexis A. Flores-GarcíaAura Hernandez-RodriguezE. Isabel López-BritoDafne F. Nava-DomínguezSebastian P. PasaperaR. Franchesca Pazos-MurilloTonatzin Pineda-DiazAlberto Vázquez-Salazar https://www.frontiersin.org/articles/10.3389/fgene.2026.1787421 https://www.frontiersin.org/articles/10.3389/fgene.2026.1787421 <![CDATA[Tumor microenvironment-induced epigenetic reprogramming of Tregs and its impact on immunotherapy]]> 2026-03-27T00:00:00Z Review Wenhao LiJiyu Tong https://www.frontiersin.org/articles/10.3389/fgene.2026.1814124 https://www.frontiersin.org/articles/10.3389/fgene.2026.1814124 <![CDATA[Correction: Association of mir-196a-2 rs11614913 and mir-149 rs2292832 polymorphisms with risk of cancer: an updated meta-analysis]]> 2026-03-25T00:00:00Z Correction Jalal ChoupaniZiba Nariman-Saleh-FamZahra SaadatianElaheh OuladsahebmadarekAndrea MasottiMilad Bastami https://www.frontiersin.org/articles/10.3389/fgene.2026.1806282 https://www.frontiersin.org/articles/10.3389/fgene.2026.1806282 <![CDATA[THGC_MDA: a method for predicting the associations between m1A modification and diseases based on ternary heterogeneous network and graph convolutional neural network]]> 2026-03-20T00:00:00Z Original Research Hongyan GaoXue ZhouLei BaiHaifeng YangFei Liu https://www.frontiersin.org/articles/10.3389/fgene.2026.1760431 https://www.frontiersin.org/articles/10.3389/fgene.2026.1760431 <![CDATA[miR-18a-5p promotes phenotypic transformation of airway smooth muscle cells by targeting SPRY1 to activate the RAS-MAPK pathway]]> 2026-03-19T00:00:00Z Original Research Lijuan HuLei Li https://www.frontiersin.org/articles/10.3389/fgene.2026.1788918 https://www.frontiersin.org/articles/10.3389/fgene.2026.1788918 <![CDATA[Molecular mediators of motion: RNA–RBP networks in exercise-induced osteoarthritis protection]]> 2026-03-12T00:00:00Z Review Yupeng YangXue WangXuchang ZhouYing LiYinghao ShenZhujun MaoJunjie LiuMi Zheng https://www.frontiersin.org/articles/10.3389/fgene.2026.1775005 https://www.frontiersin.org/articles/10.3389/fgene.2026.1775005 <![CDATA[Exercise stress and tissue remodeling: advances in exosome-mediated RNA–RBP networks in musculoskeletal injury repair and functional recovery]]> 2026-03-11T00:00:00Z Review Junjie LiuHeming ChenYupeng YangZheheng JiaYing LiXintong ZhongHuimei JiangZhujun MaoMi Zheng https://www.frontiersin.org/articles/10.3389/fgene.2026.1753495 https://www.frontiersin.org/articles/10.3389/fgene.2026.1753495 <![CDATA[Aberrant expression of the MID1 protein in neurons of Huntington’s disease brain]]> 2026-03-11T00:00:00Z Brief Research Report Adriana GeraciAnnika ReisbitzerJanina GerhardSybille Krauß https://www.frontiersin.org/articles/10.3389/fgene.2026.1749292 https://www.frontiersin.org/articles/10.3389/fgene.2026.1749292 <![CDATA[Correction: A comprehensive analysis of the prognostic characteristics of microRNAs in breast cancer]]> 2026-03-11T00:00:00Z Correction Lingying WangGui WangJiahong SongDi YaoYong WangTianyou Chen https://www.frontiersin.org/articles/10.3389/fgene.2026.1718719 https://www.frontiersin.org/articles/10.3389/fgene.2026.1718719 <![CDATA[Research advancements on the role of CircRNAs in cartilage injury within osteoarthritis]]> 2026-03-06T00:00:00Z Review Chengri LiuYanqun LiuBaojian ZhangQingyu Xu https://www.frontiersin.org/articles/10.3389/fgene.2026.1776616 https://www.frontiersin.org/articles/10.3389/fgene.2026.1776616 <![CDATA[m6AHD: a new framework for identifying abnormal N6-methyladenosine (m6A) in heart diseases based on sequencing features]]> 2026-02-25T00:00:00Z Original Research Jiajie LuYanan LiYuxiang HongDongshan LiaoGuanhua Fang https://www.frontiersin.org/articles/10.3389/fgene.2026.1781271 https://www.frontiersin.org/articles/10.3389/fgene.2026.1781271 <![CDATA[Emerging role of epigenetic mechanisms in glaucoma and their translational potential]]> 2026-02-23T00:00:00Z Mini Review Altaf A. KondkarTahira SultanTaif A. AzadSaleh A. Al-Obeidan https://www.frontiersin.org/articles/10.3389/fgene.2026.1775625 https://www.frontiersin.org/articles/10.3389/fgene.2026.1775625 <![CDATA[RNA-triggered innate immunity: friend and foe]]> 2026-02-23T00:00:00Z Mini Review Maike HenschelMaria R. ConteRocio T. Martinez-Nunez https://www.frontiersin.org/articles/10.3389/fgene.2026.1769972 https://www.frontiersin.org/articles/10.3389/fgene.2026.1769972 <![CDATA[The role of miRNAs in the development of brain metastases originating from lung adenocarcinoma]]> 2026-02-20T00:00:00Z Original Research Bernadett TornerÁlmos KleknerIstván BaloghAndrás PenyigeDóra GécziTekla GáspárGréta GesztiZsuzsanna Birkó https://www.frontiersin.org/articles/10.3389/fgene.2026.1772541 https://www.frontiersin.org/articles/10.3389/fgene.2026.1772541 <![CDATA[Regulatory roles of the circRNA–RBP axis in exercise-induced skeletal muscle remodeling: mechanistic controversies and translational illusions]]> 2026-02-20T00:00:00Z Mini Review Junjie LiuYupeng YangHeming ChenMingming LiuZhujun MaoMi Zheng https://www.frontiersin.org/articles/10.3389/fgene.2026.1566012 https://www.frontiersin.org/articles/10.3389/fgene.2026.1566012 <![CDATA[Identification of key biomarkers of telomere-related genes in diabetic nephropathy via bioinformatic analysis]]> 2026-02-04T00:00:00Z Original Research Dan YuZhipeng FengHuan YaoKe An