Frontiers in Genetics | Stem Cell Research section | New and Recent Articles https://www.frontiersin.org/journals/genetics/sections/stem-cell-research RSS Feed for Stem Cell Research section in the Frontiers in Genetics journal | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-05-11T14:05:48.748+00:00 60 https://www.frontiersin.org/articles/10.3389/fgene.2026.1786528 https://www.frontiersin.org/articles/10.3389/fgene.2026.1786528 <![CDATA[Lyar contributes to cell cycle progression and multi-lineage differentiation in mouse embryonic stem cells]]> 2026-03-20T00:00:00Z Brief Research Report Yuanqing PanYuqi SuLi XingMingze Yao https://www.frontiersin.org/articles/10.3389/fgene.2026.1774170 https://www.frontiersin.org/articles/10.3389/fgene.2026.1774170 <![CDATA[Functional validation of the novel KIF5A p.R17Q VUS reveals defective axonal transport in iPSC-motoneurons from a SPG10 patient]]> 2026-02-27T00:00:00Z Brief Research Report Serena SantangeloValeria CasiraghiClaudia FalliniSabrina InvernizziSilvia PeverelliMartina BertocchiMonica FeoleMarta CozziStefania MagriAngelo PolettiPatrizia BossolascoFranco TaroniVincenzo SilaniAntonia Ratti A (p.R17Q) in the KIF5A motor domain, classified as variant of unknown significance (VUS) and predicted to affect ATP binding. Here we gene-edited this mutant iPSC line by CRISPR-Cas9 to obtain an isogenic wild-type (WT) KIF5A cell line. We next examined functionally the impact of the p.R17Q VUS on KIF5A protein sub-cellular distribution and on axonal transport of mitochondria and lysosomes in differentiated iPSC-motoneurons (MNs). The presence of neurofilament-positive axonal swellings and an increased distribution of KIF5A protein in distal neurites was observed in the mutant p.R17Q compared to the WT KIF5A iPSC-MNs, indicating a likely defective axonal transport. The anterograde velocity and distance travelled by mitochondria and lysosomes along neurites was indeed significantly reduced in the mutant KIF5A iPSC-MNs compared to the WT ones. These findings demonstrate that the p.R17Q VUS is pathogenic, thereby extending the spectrum of KIF5A mutations causing SPG10 and support the use of patient-derived iPSC-MNs to functionally validate KIF5A-associated VUS.]]> https://www.frontiersin.org/articles/10.3389/fgene.2025.1713817 https://www.frontiersin.org/articles/10.3389/fgene.2025.1713817 <![CDATA[RNA-seq analysis reveals a positive role for NGF in the myogenic differentiation of bovine skeletal muscle satellite cells]]> 2026-01-21T00:00:00Z Original Research Xin LiZhongli ZhaoYang CaoYumin ZhaoLihong Qin https://www.frontiersin.org/articles/10.3389/fgene.2025.1701001 https://www.frontiersin.org/articles/10.3389/fgene.2025.1701001 <![CDATA[Comparative RNA-seq and functional assays identify L-arginine transporter SLC7A2 as a potential regulator of osteogenesis in maxillary sinus mucosal stem cells]]> 2025-10-28T00:00:00Z Original Research Jing RenNingbo GengTianren ZhouShiting MoChi ZhangWei PengChunhui LiaoSongling Chen https://www.frontiersin.org/articles/10.3389/fgene.2025.1639756 https://www.frontiersin.org/articles/10.3389/fgene.2025.1639756 <![CDATA[Mesenchymal stem cells and exosomes in ischemic brain injury: a review]]> 2025-08-29T00:00:00Z Mini Review Haiyan XuLanlan YangWeitie WangChengwei Zhang https://www.frontiersin.org/articles/10.3389/fgene.2025.1628178 https://www.frontiersin.org/articles/10.3389/fgene.2025.1628178 <![CDATA[Loss of dynamin 1-like protein impairs mitochondrial function and self-renewal, and activates the integrated stress response in human embryonic stem cells]]> 2025-07-28T00:00:00Z Original Research Artur Cieslar-PobudaSafak Caglayan https://www.frontiersin.org/articles/10.3389/fgene.2025.1658563 https://www.frontiersin.org/articles/10.3389/fgene.2025.1658563 <![CDATA[Correction: Reduced T-cell stemness underlies Th17 expansion and graft dysfunction in kidney transplant recipients]]> 2025-07-15T00:00:00Z Correction Chang LiuHao JiangAndu ZhuChen XuZhenfan WangGuocai MaoMinjun JiangJianchun ChenZheng MaJiaqian QiZhijun Cao https://www.frontiersin.org/articles/10.3389/fgene.2025.1588941 https://www.frontiersin.org/articles/10.3389/fgene.2025.1588941 <![CDATA[Reduced T-Cell stemness underlies Th17 expansion and graft dysfunction in kidney transplant recipients]]> 2025-06-13T00:00:00Z Original Research Chang LiuHao JiangAndu ZhuChen XuZhenfan WangGuocai MaoMinjun JiangJianchun ChenZheng MaJiaqian QiZhijun Cao https://www.frontiersin.org/articles/10.3389/fgene.2025.1592599 https://www.frontiersin.org/articles/10.3389/fgene.2025.1592599 <![CDATA[Gene expression profiles identify key factors in inflammatory odontoblastic dental pulp stem cell differentiation via TNFα/C5L2]]> 2025-06-04T00:00:00Z Original Research Muhammad IrfanJi Hyun KimSreelekshmi SreekumarSeung Chung https://www.frontiersin.org/articles/10.3389/fgene.2025.1584095 https://www.frontiersin.org/articles/10.3389/fgene.2025.1584095 <![CDATA[IGF-1 secreted by mesenchymal stem cells affects the function of lymphatic endothelial progenitor cells: a potential strategy for the treatment of lymphedema]]> 2025-05-21T00:00:00Z Original Research Zekuan XueDongdong YangZhiwei JinYijie LiYunfei YuXinchun ZhaoYongzhou HuangShengqiu JiaTong ZhangGuilin HuangJixue Hou https://www.frontiersin.org/articles/10.3389/fgene.2025.1583391 https://www.frontiersin.org/articles/10.3389/fgene.2025.1583391 <![CDATA[Frontier progress and translational challenges of pluripotent differentiation of stem cells]]> 2025-04-28T00:00:00Z Mini Review Zhengbing SuHui DongXiang FangWenli ZhangHong Duan https://www.frontiersin.org/articles/10.3389/fgene.2025.1574545 https://www.frontiersin.org/articles/10.3389/fgene.2025.1574545 <![CDATA[SAMHD1 knockout hiPSC model enables high lentiviral transduction efficiency in myeloid cell types]]> 2025-04-07T00:00:00Z Original Research Huinan LiMaliha AfrozeGunisha AroraScot FedermanKaivalya ShevadeYeqing Angela YangPhuong NguyenRustam EsanovLaralynne PrzybylaAdam LittermanShawn Shafer https://www.frontiersin.org/articles/10.3389/fgene.2025.1516626 https://www.frontiersin.org/articles/10.3389/fgene.2025.1516626 <![CDATA[Enhanced renal ischemia/reperfusion injury repair potential of exosomes derived from B7-H1high mesenchymal stem cells]]> 2025-04-02T00:00:00Z Original Research Jiahui HeYawei YaoRuiyan WangYujia LiuXingyu WanHao WangYuqiang ZhouWenjing WangYan MaXinghua Lv https://www.frontiersin.org/articles/10.3389/fgene.2024.1541992 https://www.frontiersin.org/articles/10.3389/fgene.2024.1541992 <![CDATA[Impacts of stem cells from different sources on wound healing rate in diabetic foot ulcers: a systematic review and meta-analysis]]> 2025-01-28T00:00:00Z Review Le TongLin TangBangli TangJianna Zhang https://www.frontiersin.org/articles/10.3389/fgene.2024.1407671 https://www.frontiersin.org/articles/10.3389/fgene.2024.1407671 <![CDATA[Identification of key miRNAs and target genes in extracellular vesicles derived from low-intensity pulsed ultrasound-treated stem cells]]> 2025-01-15T00:00:00Z Original Research Xin YinJialian YiFugang MaoQisheng TangXinyu ZhangXiaoyu YangHongqing XieLinping WangShuifen SunXin YuJie LiuLihong Jiang https://www.frontiersin.org/articles/10.3389/fgene.2024.1515778 https://www.frontiersin.org/articles/10.3389/fgene.2024.1515778 <![CDATA[Differential regulation of apoptosis-related genes during long-term culture and differentiation of canine adipose-derived stem cells - a functional bioinformatical analysis]]> 2025-01-06T00:00:00Z Original Research Maurycy JankowskiKatarzyna StefańskaMichał SuchodolskiClaudia DompeGrzegorz WąsiatyczBartosz KempistyMichał NowickiMagdalena Roszak https://www.frontiersin.org/articles/10.3389/fgene.2024.1538016 https://www.frontiersin.org/articles/10.3389/fgene.2024.1538016 <![CDATA[Corrigendum: Characterization of Strip1 expression in mouse cochlear hair cells]]> 2024-12-20T00:00:00Z Correction Shasha ZhangYing DongRuiying QiangYuan ZhangXiaoli ZhangYin ChenPei JiangXiangyu MaLeilei WuJingru AiXia GaoPengjun WangJie ChenRenjie Chai https://www.frontiersin.org/articles/10.3389/fgene.2024.1520519 https://www.frontiersin.org/articles/10.3389/fgene.2024.1520519 <![CDATA[Corrigendum: Advances in stem cell therapy for diabetic foot]]> 2024-12-12T00:00:00Z Correction Yinfeng XiaPing WuHong ChenZhiyong Chen https://www.frontiersin.org/articles/10.3389/fgene.2024.1421980 https://www.frontiersin.org/articles/10.3389/fgene.2024.1421980 <![CDATA[Two machine learning-derived nomogram for predicting the occurrence and severity of acute graft-versus-host disease: a retrospective study based on serum biomarkers]]> 2024-11-08T00:00:00Z Original Research Qiang HeXin LiYuan FangFansheng KongZhe YuLinna Xie 0.75. In machine learning analysis, eight features (LAG-3, TLR-2, PD-L1, IP-10, elafin, REG-3α, ST2, TIM3) and seven variables (LAG-3, TLR-2, PD-1, Flt_3, IL-9, elafin, TIM3) were selected to distinguish aGVHD vs. non-aGVHD as well as grade I/II vs. III/IV, respectively. Further, the corresponding nomogram models were established and calibration curves showed that prediction was in good agreement with the actual probability. Biomarker-based risk score model was constructed, which obtained AUC value >0.89 in internal and external datasets.ConclusionClinical variables screened through learning algorithm can predict the risk and severity of aGVHD. Our findings may help clinicians develop more personalized and reasonable management strategies.]]> https://www.frontiersin.org/articles/10.3389/fgene.2024.1427205 https://www.frontiersin.org/articles/10.3389/fgene.2024.1427205 <![CDATA[Advances in stem cell therapy for diabetic foot]]> 2024-09-03T00:00:00Z Mini Review Yinfeng XiaPing WuHong ChenZhiyong Chen