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The section Genome Engineering and Neurologic Disorders explores the role of genome engineering across the spectrum of brain function and dysfunction. Original papers and reviews for the efficient use and delivery of editing tools in the brain, as well as advances that overcome special challenges related to the genetic or epigenetic manipulation in the central nervous system are welcome.
• Tools and methods for editing DNA, RNA, epigenetic information, or gene expression in relation to neurologic or psychiatric disorders
• Using editing to create or learn from disease-relevant cell and animal model systems to improve understanding of typical or atypical neurological conditions
• Genetic screens (CRISPRa/i/n or similar) to identify genes involved in neurologic function or disease
• Studies that elucidate how genes or gene expression affect neurologic phenotype (behaviors, structures, outcomes)
• Editing used to study or treat neurodevelopmental, neurodegenerative, induced (e.g., early life stress, environment, trauma) neurologic or psychiatric disorders
• Innovative methods for the delivery of editing tools to the CNS, including responses to such methods
• Innovative gene and epigenetic editing therapies in preclinical or clinical testing phases
Topics not appropriate for this section:
• Studies unrelated to neurologic or psychiatric disorders
• General tools or delivery methods development that do not focus on the CNS
• Studies of neurologic/psychiatric disorders or normal brain function that do not involve editing
Indexed in: CLOCKSS, CrossRef, DOAJ, Google Scholar, OpenAIRE, PubMed Central (PMC)
Genome Engineering and Neurologic Disorders welcomes submissions of the following article types: Brief Research Report, Correction, Editorial, General Commentary, Hypothesis and Theory, Methods, Mini Review, Opinion, Original Research, Perspective, Policy and Practice Reviews, Policy Brief and Review.
All manuscripts must be submitted directly to the section Genome Engineering and Neurologic Disorders, where they are peer-reviewed by the Associate and Review Editors of the specialty section.
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For all queries regarding manuscripts in Review and potential conflicts of interest, please contact firstname.lastname@example.org
For queries regarding Research Topics, Editorial Board applications, and journal development, please contact email@example.com