AUTHOR=Baynes Colin , Steyn Petrus , Soi Caroline , Dinis Aneth , Tembe Stelio , Mehrtash Hedieh , Narasimhan Manjulaa , Kiarie James , Sherr Kenneth TITLE=Use of implementation science to advance family planning programs in low- and middle-income countries: A systematic review JOURNAL=Frontiers in Global Women's Health VOLUME=Volume 3 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/global-womens-health/articles/10.3389/fgwh.2022.1038297 DOI=10.3389/fgwh.2022.1038297 ISSN=2673-5059 ABSTRACT=Objective: As environmental and economic pressures converge with demands to achieve sustainability development goals, low- and middle-income countries (LMIC) increasingly require strategies to strengthen and scale-up evidence-based practices (EBP) related to family planning (FP). Implementation science (IS) can help these efforts. The purpose of this article is to elucidate patterns in the use of IS in FP research and identify ways to maximize the potential of IS to advance FP in LMIC. Design and methods: We conducted a systematic review that describes how IS concepts and principles have been operationalized in LMIC FP research published from 2007-2021. We searched six databases for implementation studies of LMIC FP interventions. Our review synthesizes the characteristics of implementation strategies and research efforts used to enhance the performance of FP-related EBP in these settings, identifying gaps, strengths and lessons learned. Results: 472 studies were eligible for full-text review. Fifty-four percent were on strategies that promoted individuals’ uptake of FP. Far fewer were on strategies to enhance the coverage, implementation, spread or sustainability of FP programs. Most studies used quantitative methods only and evaluated user-level outcomes over implementation outcomes. Thirty percent measured processes and outcomes of strategies, 15% measured changes in implementation outcomes, and 31% report on the effect of contextual factors. Eighteen percent reported that they were situated within decision-making processes to address locally identified implementation issues. Fourteen percent described measures to involve stakeholders in the research process. Only 7% of studies reported that implementation was led by LMIC delivery systems or implementation partners. Conclusions: IS has potential to further advance LMIC FP programs, although its impact will be limited unless its concepts and principles are incorporated more systematically. To support this, stakeholders must focus on strategies that address a wider range of implementation outcomes; adapt research designs and blend methods to evaluate outcomes and processes; and establish collaborative research efforts across implementation, policy, and research domains. Doing so will expand opportunities for learning and applying new knowledge in pragmatic research paradigms where research is embedded in usual implementation conditions and addresses critical issues such as scale up and sustainability of evidence-informed FP interventions.