https://www.frontiersin.org/journals/hematology RSS Feed for Frontiers in Hematology | New and Recent Articles en-us Frontiers Feed Generator,version:1 2026-08-21T06:32:57.990+00:00 60 https://www.frontiersin.org/articles/10.3389/frhem.2026.1870201 https://www.frontiersin.org/articles/10.3389/frhem.2026.1870201 2026-08-05T00:00:00Z Case Report Henry ZouAkram AlnounouTessa KravchenkoMorgan SmeltzerCameron Schaecher https://www.frontiersin.org/articles/10.3389/frhem.2026.1766692 https://www.frontiersin.org/articles/10.3389/frhem.2026.1766692 2026-06-29T00:00:00Z Original Research Apoorva JagadishYouwei ChenHongmei ZhuWeijia MaiShein-Chung ChowZhong LiGrace M. LeeMarilyn J. TelenTim J. McMahon https://www.frontiersin.org/articles/10.3389/frhem.2026.1850831 https://www.frontiersin.org/articles/10.3389/frhem.2026.1850831 2026-06-26T00:00:00Z Review Arunim ShahArun Kumar TrivediChandra Prakash Chaturvedi https://www.frontiersin.org/articles/10.3389/frhem.2026.1874214 https://www.frontiersin.org/articles/10.3389/frhem.2026.1874214 2026-06-24T00:00:00Z Case Report Anna GiordanoValentina BodanzaFrancesco AngotziAlessandro CelliniArianna BevilacquaMattia D’AntigaMartina De FerrariValeria PergolaElena CampelloLivio TrentinAndrea Visentin https://www.frontiersin.org/articles/10.3389/frhem.2026.1813321 https://www.frontiersin.org/articles/10.3389/frhem.2026.1813321 2026-06-22T00:00:00Z Original Research Alan J. PootsSamantha NierSarah GunnSam Salek https://www.frontiersin.org/articles/10.3389/frhem.2026.1826416 https://www.frontiersin.org/articles/10.3389/frhem.2026.1826416 2026-06-11T00:00:00Z Original Research Alexander C. AngleitnerMarkus MaulhardtJustin HasenkampJudith BüntzelGerald Wulf https://www.frontiersin.org/articles/10.3389/frhem.2026.1814036 https://www.frontiersin.org/articles/10.3389/frhem.2026.1814036 2026-06-10T00:00:00Z Hypothesis and Theory Emily ProudmanPhilip Savage https://www.frontiersin.org/articles/10.3389/frhem.2026.1851998 https://www.frontiersin.org/articles/10.3389/frhem.2026.1851998 2026-05-29T00:00:00Z Systematic Review Mohamed M. KhamisNehemias Antonio Guevara RodriguezRanju Kunwor 10 × 109/L) accounts for 20%–30% of cases with early mortality of 15%–25%. Optimal induction with reduced-intensity all-trans retinoic acid plus arsenic trioxide (ATRA+ATO) versus intensive chemotherapy remains debated.MethodsFollowing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (PROSPERO CRD420261293473), we searched PubMed and Cochrane Library (2000–2025). Reduced-intensity: ATRA+ATO with gemtuzumab ozogamicin (GO; 6–9 mg/m2), low-dose idarubicin (one to two doses of 12 mg/m2), or hydroxyurea; intensive: ATRA-based therapy with three or more anthracycline doses. Random-effects meta-analysis used logit transformation and inverse variance weighting. RoB 2 and ROBINS-I were used to assess risk of bias.ResultsA total of 17 studies (1,323 patients, 11 on the reduced-intensity arm and 14 on the intensive arm) were included. Complete remission (CR) was 92.3% (95%CI = 85.9–95.9%, I2 = 0%) versus 89.3% (82.6%–93.6%, I2 = 56%, p = 0.35). Early mortality was 8.8% versus 10.4% (p = 0.62). Event-free survival (EFS) from two randomized controlled trials (RCTs) favored reduced-intensity induction (HR = 0.23, 95%CI= 0.07–0.76, p = 0.015). Relapse was 3.9% versus 5.5% (p = 0.49). WBC-stratified CR remained stable at 91.6%–92.5% with reduced-intensity induction, while intensive CR declined from 96.0% to 86.6% at WBC ≥30 × 109/L.ConclusionsReduced-intensity ATRA+ATO-based induction achieves equivalent CR, comparable early mortality, superior EFS (HR = 0.23, p = 0.015), and lower relapse, supporting ATRA+ATO with GO or low-dose anthracycline as the preferred first-line therapy for high-risk APL.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD420261293473.]]> https://www.frontiersin.org/articles/10.3389/frhem.2026.1779396 https://www.frontiersin.org/articles/10.3389/frhem.2026.1779396 2026-05-21T00:00:00Z Original Research Himanshu DhandaShamsuz ZamanBhavika RishiRaj KamalManpreet KaurNitika AnandBaseer NoorPranay TanwarSufian ZaheerPrashant PrabhakarFouzia SirajAmitabh SinghAroonima Misra https://www.frontiersin.org/articles/10.3389/frhem.2026.1812908 https://www.frontiersin.org/articles/10.3389/frhem.2026.1812908 2026-05-13T00:00:00Z Mini Review Julia A. YescasChristopher G. BunickAyman GradaJoan GuitartCarlos A. Torres-CabalaI. Caroline Le PooleXiaolong A. Zhou https://www.frontiersin.org/articles/10.3389/frhem.2026.1813861 https://www.frontiersin.org/articles/10.3389/frhem.2026.1813861 2026-05-11T00:00:00Z Review Renato Luiz Guerino-CunhaAndreia BessaAngela Marie JansenMartha OliveiraGayatri SankuRogerio ScarabelJayr Schmidt-FilhoStephen Stefani https://www.frontiersin.org/articles/10.3389/frhem.2026.1800304 https://www.frontiersin.org/articles/10.3389/frhem.2026.1800304 2026-05-04T00:00:00Z Original Research Eilidh M DuncanJhulia SalvianoCharalampia KyriakouSamantha NierSimone OerlemansSam SalekKate MorganKatie Joyner https://www.frontiersin.org/articles/10.3389/frhem.2026.1733719 https://www.frontiersin.org/articles/10.3389/frhem.2026.1733719 2026-04-13T00:00:00Z Case Report Alexander KruleCarlos Murga-ZamalloaIrum KhanRyan SunJohn G. Quigley https://www.frontiersin.org/articles/10.3389/frhem.2025.1650494 https://www.frontiersin.org/articles/10.3389/frhem.2025.1650494 2026-04-08T00:00:00Z Case Report Carlos R. VarónSantiago Andrés Suárez-GómezDaniela VarónLibelly Gómez FlórezCarolina Cortes-UrreaElda Graciela Vélez ColmenaresIsabella Corona A (p.R3155Q), classified as a variant of uncertain significance. This report underscores the diagnostic and therapeutic challenges in rare hematologic malignancies, emphasizing the importance of genetic characterization through next-generation sequencing and advocating for improved awareness, early diagnosis, and multidisciplinary management strategies for optimal outcomes in CHS-associated malignancies.]]> https://www.frontiersin.org/articles/10.3389/frhem.2026.1749376 https://www.frontiersin.org/articles/10.3389/frhem.2026.1749376 2026-03-31T00:00:00Z Review Gökhan MergenHans C. Hasselbalch https://www.frontiersin.org/articles/10.3389/frhem.2026.1770034 https://www.frontiersin.org/articles/10.3389/frhem.2026.1770034 2026-03-30T00:00:00Z Original Research Arielle L. LangerAmey RaneKeely S. GilroyJing ZhaoLouise LombardCarolyn R. LewSujit Sheth https://www.frontiersin.org/articles/10.3389/frhem.2026.1727954 https://www.frontiersin.org/articles/10.3389/frhem.2026.1727954 2026-03-30T00:00:00Z Case Report Elinor BarshMichele BascheDmitriy Scherbak https://www.frontiersin.org/articles/10.3389/frhem.2026.1812817 https://www.frontiersin.org/articles/10.3389/frhem.2026.1812817 2026-03-27T00:00:00Z Editorial Bhavana BhatnagarSrinivas Devarakonda https://www.frontiersin.org/articles/10.3389/frhem.2026.1785387 https://www.frontiersin.org/articles/10.3389/frhem.2026.1785387 2026-03-26T00:00:00Z Perspective Chao-Chieh ChengRuo-Han ChinPo-Cheng ShihSu-Boon YongChia-Jung Li https://www.frontiersin.org/articles/10.3389/frhem.2026.1802350 https://www.frontiersin.org/articles/10.3389/frhem.2026.1802350 2026-03-18T00:00:00Z Methods Léa GirondierManon RichaudJulien MP GrenierAna Belen Pérez-OlivaJenny Van Asbeck-van der WijstMichel Aurrand-LionsMaria De GrandisChristophe LachaudCyril FauriatLaura Braud