AUTHOR=Weingram Adam , Cui Carolyn , Lin Stephanie , Munoz Samuel , Jacob Toby , Viers Joshua , Lu Xiaoyi 

TITLE=A definition and taxonomy of digital twins: case studies with machine learning and scientific applications

JOURNAL=Frontiers in High Performance Computing

VOLUME=Volume 3 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/high-performance-computing/articles/10.3389/fhpcp.2025.1536501

DOI=10.3389/fhpcp.2025.1536501

ISSN=2813-7337

ABSTRACT=As next-generation scientific instruments and simulations generate ever larger datasets, there is a growing need for high-performance computing (HPC) techniques that can provide timely and accurate analysis. With artificial intelligence (AI) and hardware breakthroughs at the forefront in recent years, interest in using this technology to perform decision-making tasks with continuously evolving real-world datasets has increased. Digital twinning is one method in which virtual replicas of real-world objects are modeled, updated, and interpreted to perform such tasks. However, the interface between AI techniques, digital twins (DT), and HPC technologies has yet to be thoroughly investigated despite the natural synergies between them. This paper explores the interface between digital twins, scientific computing, and machine learning (ML) by presenting a consistent definition for the digital twin, performing a systematic analysis of the literature to build a taxonomy of ML-enhanced digital twins, and discussing case studies from various scientific domains. We identify several promising future research directions, including hybrid assimilation frameworks and physics-informed techniques for improved accuracy. Through this comprehensive analysis, we aim to highlight both the current state-of-the-art and critical paths forward in this rapidly evolving field.