AUTHOR=Ding Xuejiao , Peng Dantao 

TITLE=Transient Global Amnesia: An Electrophysiological Disorder Based on Cortical Spreading Depression—Transient Global Amnesia Model

JOURNAL=Frontiers in Human Neuroscience

VOLUME=Volume 14 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2020.602496

DOI=10.3389/fnhum.2020.602496

ISSN=1662-5161

ABSTRACT=Transient global amnesia (TGA) is a benign memory disorder with etiologies under long-term debate. The prevalence of stressful events before TGA attack make these precipitating factors not to be easily overlooked, given stress has the potential to make organic effect on the brain. Cortical spreading depression (CSD) has been proposed as a possible cause decades ago. Being a regional phenomenon, CSD seems to affect every aspect of micro-mechanism in maintaining the homeostasis of the central nervous system (CNS). Corresponding evidences regarding hemodynamic and morphological changes from TGA and CSD have been accumulated separately, but the resemblance between the two has not be systematically explored so far, especially considering CSD had been confirmed to cause secondary damage in the human brain. Thus, by delving deep into the anatomic and electrophysiological properties of the CNS, CSD-TGA model may render insights into the basic pathophysiology behind the façade of the enigmatic clinical presentation.