AUTHOR=Jiang Weiwei , Sun Jintao , Xiang Jing , Sun Yulei , Tang Lu , Zhang Ke , Chen Qiqi , Wang Xiaoshan 

TITLE=Altered Neuromagnetic Activity in Persistent Postural-Perceptual Dizziness: A Multifrequency Magnetoencephalography Study

JOURNAL=Frontiers in Human Neuroscience

VOLUME=Volume 16 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2022.759103

DOI=10.3389/fnhum.2022.759103

ISSN=1662-5161

ABSTRACT=Objective: The aim of our study was to investigate abnormal changes in brain activity in patients with persistent postural-perceptual dizziness (PPPD) using magnetoencephalography (MEG).
Methods: MEG recordings from 18 PPPD patients and 18 healthy controls were analyzed to determine the source of brain activity in seven frequency ranges using accumulated source imaging (ASI).
Results: Our study showed that abnormal changes in the temporal-parietal junction (TPJ) were observed at 1-4 Hz, 4-8 Hz, and 12-30 Hz in PPPD patients compared with healthy controls, and changes in the frontal cortex were found at 1-4 Hz, 80-250 Hz, and 250-500 Hz in PPPD patients compared with controls. There was no significant difference in source strength between the PPPD and control groups.
Conclusion: Our results demonstrated that alterations in the TPJ and frontal cortex may play a critical role in the pathophysiological mechanism of PPPD and that frequency-dependent changes in brain activity were also involved in the pathophysiology of PPPD.