AUTHOR=Schönthaler Elena M. D. , Dalkner Nina , Stross Tatjana , Bengesser Susanne , Ilic Julia , Fellendorf Frederike , Finner Alexander , Fleischmann Eva , Häussl Alfred , Georgi Johanna , Maget Alexander , Lenger Melanie , Painold Annamaria , Platzer Martina , Queissner Robert , Schmiedhofer Franziska , Smolle Stefan , Tmava-Berisha Adelina , Reininghaus Eva Z. 

TITLE=Cognitive abilities and psychosocial functioning in bipolar disorder: findings from the BIPLONG study

JOURNAL=Frontiers in Human Neuroscience

VOLUME=Volume 19 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2025.1479648

DOI=10.3389/fnhum.2025.1479648

ISSN=1662-5161

ABSTRACT=BackgroundBipolar disorder is associated with impairments in cognition and psychosocial functioning. Although these impairments occur frequently, often persist during euthymic times, and worsen quality of life, the impact of cognitive abilities on functioning has not yet been fully elucidated.MethodsThe current study investigated the effects of cognitive domains (attention/psychomotor speed, verbal learning/memory, executive function) on psychosocial functioning cross-sectionally. Data from 210 euthymic individuals with bipolar disorder [101 female, 109 male; M(age) = 44.47; SD(age) = 14.25] were included into the analysis. A neurocognitive test battery was administered and the Global Assessment of Functioning was used to depict psychosocial functioning. Correlation analyses were conducted to observe the associations between functioning and the cognitive domains. Moreover, three hierarchical regression analyses were applied to predict functioning by each of the cognitive domains, while considering age, sex, and education as control variables.ResultsCorrelation analyses revealed that functioning was positively associated with attention/psychomotor speed and verbal learning/memory. However, the consecutive hierarchical regression analyses found that none of the cognitive domains were able predict functioning beyond the control variables age, sex, and education.ConclusionOur findings indicate that greater abilities in the domains of attention/psychomotor speed and verbal learning/memory are associated with better functioning. However, this association can be explained by other relevant variables such as age or education, indicating that cognitive abilities are not the sole contributor of psychosocial functioning. Investigating other measurements of functioning or cognitive abilities could lead to different results. Nevertheless, promoting cognitive abilities and autonomy in daily life remains an important aspect of therapy in bipolar disorder.