AUTHOR=Fujita Kohei , Takeuchi Nobuyuki , Sugiyama Shunsuke , Inui Koji , Fujita Yuki , Yamaba Ami , Kamiya Taeko , Ushida Takahiro , Kanemoto Kousuke , Miyata Jun , Nishihara Makoto 

TITLE=Loudness dependence of auditory evoked potentials reflects trait anxiety and harm avoidance in healthy adults: an exploratory study

JOURNAL=Frontiers in Human Neuroscience

VOLUME=Volume 19 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/human-neuroscience/articles/10.3389/fnhum.2025.1615407

DOI=10.3389/fnhum.2025.1615407

ISSN=1662-5161

ABSTRACT=Loudness dependence of auditory-evoked potentials (LDAEP), a neurophysiological measure that reflects central serotonergic activity, is also influenced by the noradrenaline and dopamine systems. While it has been used in investigations of various psychiatric disorders, the fundamental characteristics in healthy individuals remain largely unknown. The present exploratory study examined 60 healthy adults to determine the associations of LDAEP with psychological traits assessed using the Temperament and Character Inventory (TCI) and State-Trait Anxiety Inventory (STAI). The participants completed TCI and STAI questionnaires before undergoing electrophysiological recordings. LDAEP was measured based on the peak-to-peak amplitude slopes of P50/N100 and N100/P200 across five sound intensity levels. Using Spearman's correlation analysis, moderate negative correlations of LDAEP slopes with harm avoidance (HA) and trait anxiety (STAI-T) scores were noted. Additionally, sex-adjusted analysis showed novelty seeking to be positively associated with LDAEP. These findings suggest an association of LDAEP with individual differences in harm avoidance, trait anxiety, and novelty seeking in healthy adults. This supports the potential use of LDAEP as a non-invasive biomarker to predict treatment response in major depressive disorder, as well as in anxiety-related conditions.