AUTHOR=Chowdhury Roshni R., Ghosh Swapan K. TITLE=Phytol-Derived Novel Isoprenoid Immunostimulants JOURNAL=Frontiers in Immunology VOLUME=Volume 3 - 2012 YEAR=2012 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2012.00049 DOI=10.3389/fimmu.2012.00049 ISSN=1664-3224 ABSTRACT=This review describes the adjuvanticity of novel diterpenoids (synthetic phytol derivatives) compared to some commercially available adjuvants. The efficacy of the phytol-derived immunostimulants was evaluated in terms of their ability to activate innate immunity, amplify various antigen-specific immune responses and engender immunological memory with no discernible adverse effects in both competent and immune-deficient mice. The profile that emerges out of these studies reveals that the phytol derivatives are excellent immunostimulants, superior in many respects to a number of commercial adjuvants.