AUTHOR=Cancro Michael P., Scholz Jean L., Sindhava Vishal J.

TITLE=Roles for BLyS family members in meeting the distinct homeostatic demands of innate and adaptive B cells

JOURNAL=Frontiers in Immunology

VOLUME=Volume 4 - 2013

YEAR=2013

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2013.00037

DOI=10.3389/fimmu.2013.00037

ISSN=1664-3224

ABSTRACT=B-1 and B-2 B cell populations have different progenitors, receptor diversity, anatomic location, and functions -- suggesting vastly difffering requisites for homeostatic regulation.  There is evidence that the BLyS family of cytokines and receptors, key factors in the homeostatic regulation of B-2 B cell subsets, is also a major player in the B-1 compartment.  Here we review the development and differentiation of these two primary B cell lineages and their immune functions.  We discuss evidence that BLyS or APRIL availability in different anatomic sites, coupled with signature BLyS receptor expression patterns on different B cell subsets, may be important for homeostatic regulation of B-1 as well as B-2 populations.  Finally, we extend our working model of B cell homeostasis to integrate B-1s.