AUTHOR=Danger Richard , Braza Faouzi , Giral Magali , Soulillou Jean-Paul , Brouard Sophie 

TITLE=MicroRNAs, Major Players in B Cells Homeostasis and Function

JOURNAL=Frontiers in Immunology

VOLUME=Volume 5 - 2014

YEAR=2014

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2014.00098

DOI=10.3389/fimmu.2014.00098

ISSN=1664-3224

ABSTRACT=As a main actor in humoral immunity, B cells participate in various antibody-related disorders. However, a deeper understanding of B-cell differentiation and function is needed in order to decipher their immune-modulatory roles, notably with the recent highlighting of regulatory B cells. microRNAs (miRNAs), key factors in various biological and pathological processes, have been shown to be essential for B cell homeostasis, and therefore understanding their participation in B cell biology could help identify biomarkers and contribute towards curing B-cell related immune disorders. This review aims to report studies casting light on the roles played by microRNAs in B-cell lineage and function and B cell-related immune pathologies.