AUTHOR=Ferlazzo Guido , Morandi Barbara 

TITLE=Cross-Talks between Natural Killer Cells and Distinct Subsets of Dendritic Cells

JOURNAL=Frontiers in Immunology

VOLUME=Volume 5 - 2014

YEAR=2014

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2014.00159

DOI=10.3389/fimmu.2014.00159

ISSN=1664-3224

ABSTRACT=In recent years, the essential role of bidirectional cross-talk between natural killer (NK) and dendritic cells (DC) during immune responses has been clearly elucidated. In particular, this cross-talk results in the development of an efficient innate response, through DC-mediated NK cell activation, and a potent adaptive immune response, through NK-mediate DC editing and maturation. <br/>Recently, some novel human DC subsets have been identified: migratory DCs in afferent lymph and draining lymph nodes; CLEC9A+/ BDCA3+ DCs in interstitial dermis, liver, lung; inflammatory DCs in several fluids secondary to flogosis. At the same time, it has been shown that also human NK cells are present in these compartments. <br/>Here we will review the most recent findings on NK/DC cross-talk and we will discuss the necessity of acquiring more complete knowledge about these interactions in view of the new information available on both DC and NK cell subsets.  <br/>