AUTHOR=Ruocco Maria Grazia , Chaouat Gérard , Florez Laura , Bensussan Armand , Klatzmann David 

TITLE=Regulatory T-Cells in Pregnancy: Historical Perspective, State of the Art, and Burning Questions

JOURNAL=Frontiers in Immunology

VOLUME=Volume 5 - 2014

YEAR=2014

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2014.00389

DOI=10.3389/fimmu.2014.00389

ISSN=1664-3224

ABSTRACT=In this review, we first revisit the original concept of “suppressor T cells” in pregnancy, put it in a historical perspective and then highlight the main data that licensed its resurrection and revision into the concept of “regulatory T cells” (Tregs) in pregnancy. We review the evidence for a major role of Tregs in murine and human pregnancy and discuss Treg interactions with dendritic and uterine natural killer cells, other players of maternal-fetal tolerance. Finally, we highlight what we consider as the most important questions in the field.