AUTHOR=Byersdorfer Craig Alan 

TITLE=The Role of Fatty Acid Oxidation in the Metabolic Reprograming of Activated T-Cells

JOURNAL=Frontiers in Immunology

VOLUME=5

YEAR=2014

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2014.00641

DOI=10.3389/fimmu.2014.00641

ISSN=1664-3224

ABSTRACT=<p>Activation represents a significant bioenergetic challenge for T-cells, which must undergo metabolic reprogramming to keep pace with increased energetic demands. This review focuses on the role of fatty acid metabolism, both <italic>in vitro</italic> and <italic>in vivo</italic>, following T-cell activation. Based upon previous studies in the literature, as well as accumulating evidence in allogeneic cells, I propose a multi-step model of <italic>in vivo</italic> metabolic reprogramming. In this model, a primary determinant of metabolic phenotype is the ubiquity and duration of antigen exposure. The implications of this model, as well as the future challenges and opportunities in studying T-cell metabolism, will be discussed.</p>