AUTHOR=Hughes Catherine E. , Benson Robert A. , Bedaj Marija , Maffia Pasquale 

TITLE=Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs

JOURNAL=Frontiers in Immunology

VOLUME=7

YEAR=2016

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2016.00481

DOI=10.3389/fimmu.2016.00481

ISSN=1664-3224

ABSTRACT=<p>Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterized by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures. In this mini review, we will discuss the role of antigen-presenting cells and mechanisms of antigen presentation in TLOs, summarizing what is currently known about this facet of the formation and function of these tissues as well as identifying questions yet to be addressed.</p>