AUTHOR=Song Jialin , Ouyang Yuanming , Che Junyi , Li Xiaoming , Zhao Yi , Yang Kejia , Zhao Xiaotian , Chen Yinghui , Fan Cunyi , Yuan Weien 

TITLE=Potential Value of miR-221/222 as Diagnostic, Prognostic, and Therapeutic Biomarkers for Diseases

JOURNAL=Frontiers in Immunology

VOLUME=Volume 8 - 2017

YEAR=2017

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.00056

DOI=10.3389/fimmu.2017.00056

ISSN=1664-3224

ABSTRACT=MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression by base-pairing with their target messenger RNAs (mRNAs). Dysregulation of miRNAs is involved in the pathological initiation and progression of many human diseases. MiR-221 and miR-222 (miR-221/222) are two highly homologous miRNAs and they are significantly overexpressed in several types of human diseases. Silencing miR-221/222 could represent a promising approach for therapeutic studies. In the present review, we will describe the potential value of miR-221/222 as diagnostic, prognostic and therapeutic biomarkers in a variety of diseases including cancer and inflammatory diseases.