AUTHOR=Gardiner Clair M. , Finlay David K. 

TITLE=What Fuels Natural Killers? Metabolism and NK Cell Responses

JOURNAL=Frontiers in Immunology

VOLUME=Volume 8 - 2017

YEAR=2017

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.00367

DOI=10.3389/fimmu.2017.00367

ISSN=1664-3224

ABSTRACT=There is a growing appreciation that cellular metabolism is important in determining the course of lymphocyte responses. Additionally, changes in metabolic processes have been linked to dysfunctional lymphocyte functions in a number of different diseases. While most early studies of metabolic regulation of lymphocyte function focused on T lymphocytes, an understanding of how metabolic pathways impact upon NK cell responses is now starting to emerge. In this review article we will discuss how cellular metabolism influences lymphocyte function with a particular focus upon NK cells.