AUTHOR=Dickinson Anne M. , Norden Jean , Li Shuang , Hromadnikova Ilona , Schmid Christoph , Schmetzer Helga , Jochem-Kolb Hans 

TITLE=Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia

JOURNAL=Frontiers in Immunology

VOLUME=8

YEAR=2017

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.00496

DOI=10.3389/fimmu.2017.00496

ISSN=1664-3224

ABSTRACT=<p>The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells <italic>via</italic> a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or <italic>via</italic> donor lymphocyte infusion. GvL effects can also be initiated by allogenic mismatched natural killer cells, antigen-specific T cells, and activated dendritic cells of leukemic origin. The history and further application of this GvL effect and the main mechanisms will be discussed and reviewed in this chapter.</p>