AUTHOR=Dickinson Anne M. , Norden Jean , Li Shuang , Hromadnikova Ilona , Schmid Christoph , Schmetzer Helga , Jochem-Kolb Hans 

TITLE=Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia

JOURNAL=Frontiers in Immunology

VOLUME=Volume 8 - 2017

YEAR=2017

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.00496

DOI=10.3389/fimmu.2017.00496

ISSN=1664-3224

ABSTRACT=The success of haematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukaemia cells via a graft versus leukaemia effect, caused either spontaneously post HSCT or via donor lymphocyte infusion. Graft versus leukaemia effects can also be initiated by allogeneic mismatched NK cells, antigen specific T cells and activated dendritic cells of leukemic origin. 
The history and further application of this graft versus leukaemia effect and the main mechanisms will be discussed and reviewed in this chapter.