AUTHOR=Kopitar-Jerala Nataša 

TITLE=The Role of Interferons in Inflammation and Inflammasome Activation

JOURNAL=Frontiers in Immunology

VOLUME=Volume 8 - 2017

YEAR=2017

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.00873

DOI=10.3389/fimmu.2017.00873

ISSN=1664-3224

ABSTRACT=Inflammation is an essential physiological process which enables survival during infection and maintains tissue homeostasis.  Interferons and pro- and anti- inflammatory cytokines are crutial for appropriate response to pathogens, damaged cells or irritants in inflamamtory response. The inflammasom is multiprotein complex which initiates cleavage of pro-inflammatory cytokines IL-1β and IL-18 into active forms. In addition, inflammasomes initiate pyroptotic cell death. In the present review I summarize and analyze recent findings regarding  the crosstalk of interferons and inflammasomes.