AUTHOR=Shehata Hesham M. , Murphy Andrew J. , Lee Man kit Sam , Gardiner Clair M. , Crowe Suzanne M. , Sanjabi Shomyseh , Finlay David K. , Palmer Clovis Steve 

TITLE=Sugar or Fat?—Metabolic Requirements for Immunity to Viral Infections

JOURNAL=Frontiers in Immunology

VOLUME=Volume 8 - 2017

YEAR=2017

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01311

DOI=10.3389/fimmu.2017.01311

ISSN=1664-3224

ABSTRACT=The realization that an intricate link exists between the metabolic state of immune cells and the nature of the elicited immune responses has brought a dramatic evolution to the field of immunology. We will focus on how metabolic reprogramming through the use of glycolysis and fatty acid oxidation (sugar or fat) regulates the capacity of immune cells to mount robust and effective immune responses. We will also discuss how fine-tuning sugar and fat metabolism may be exploited as a novel immunotherapeutic strategy to fight viral infections or improve vaccine efficacy.