AUTHOR=van Eden Willem , Jansen Manon A. A. , de Wolf A Charlotte MT , Ludwig Irene S. , Leufkens Paul , Broere Femke 

TITLE=The Immunomodulatory Potential of tolDCs Loaded with Heat Shock Proteins

JOURNAL=Frontiers in Immunology

VOLUME=Volume 8 - 2017

YEAR=2017

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2017.01690

DOI=10.3389/fimmu.2017.01690

ISSN=1664-3224

ABSTRACT=Disease suppressive T cell regulation may depend on cognate interactions of regulatory T cells (Tregs) with self-antigens that are abundantly expressed in the inflamed tissues. Heat shock proteins (HSPs) are by their nature up-regulated in stressed cells and therefore abundantly present as potential targets for such regulation. HSP immunizations have led to inhibition of experimentally induced inflammatory conditions in various models. However, re-establishment of tolerance in the presence of an ongoing inflammatory process has remained challenging. Since tolerogenic DCs (tolDCs) have the combined capacity of mitigating antigen-specific inflammatory responses and of endowing T cells with regulatory potential, it seems attractive to combine the anti-inflammatory qualities of tolDCs with those of HSPs.