AUTHOR=Hippen Keli L. , Loschi Michael , Nicholls Jemma , MacDonald Kelli P. A. , Blazar Bruce R. 

TITLE=Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease

JOURNAL=Frontiers in Immunology

VOLUME=Volume 9 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.00057

DOI=10.3389/fimmu.2018.00057

ISSN=1664-3224

ABSTRACT=Regulatory T cells (Treg), are key mediators of the immune system. MicroRNAs (miRNAs) are a family of ~22 nucleotide non-coding RNAs that are processed from longer precursors by the RNases Drosha and Dicer. MiRNA regulate protein expression post-transcriptionally through mRNA destabilization or translational silencing. A critical role for miRNA in Treg function was initially discovered when both Dicer and Drosha knockout mice were found to develop a fatal autoimmune disease phenotypically similar to Foxp3 knockout mice.