AUTHOR=Tang Juan , Lin Guoxin , Langdon Wallace Y. , Tao Lijian , Zhang Jian 

TITLE=Regulation of C-Type Lectin Receptor-Mediated Antifungal Immunity

JOURNAL=Frontiers in Immunology

VOLUME=Volume 9 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.00123

DOI=10.3389/fimmu.2018.00123

ISSN=1664-3224

ABSTRACT=Of all the pathogen recognition receptor (PRR) families, C-type lectin receptor (CLR)-induced intracellular signal cascades are indispensable for the initiation and regulation of anti-fungal immunity. Ongoing experiments over the last decade have elicited diverse CLR functions and novel regulatory mechanisms of CLR-mediated signaling pathways. In this review, we highlight novel insights in anti-fungal innate and adaptive protective immunity mediated by CLRs, and discuss the potential therapeutic strategies against fungal infection based on targeting the mediators in the host immune system.