AUTHOR=Dunne Pádraic J. , Maher Christina O. , Freeley Michael , Dunne Katie , Petrasca Andreea , Orikiiriza Judy , Dunne Margaret R. , Reidy Derval , O’Dea Siobhan , Loy Aisling , Woo Jim , Long Aideen , Rogers Thomas R. , Mulcahy Fiona , Doherty Derek G. TITLE=CD3ε Expression Defines Functionally Distinct Subsets of Vδ1 T Cells in Patients With Human Immunodeficiency Virus Infection JOURNAL=Frontiers in Immunology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.00940 DOI=10.3389/fimmu.2018.00940 ISSN=1664-3224 ABSTRACT=
Human γδ T cells expressing the Vδ1 T cell receptor (TCR) recognize self and microbial antigens and stress-inducible molecules in a major histocompatibility complex-unrestricted manner and are an important source of innate interleukin (IL)-17. Vδ1 T cells are expanded in the circulation and intestines of patients with human immunodeficiency virus (HIV) infection. In this study, we show that patients with HIV have elevated frequencies, but not absolute numbers, of circulating Vδ1 T cells compared to control subjects. This increase was most striking in the patients with