AUTHOR=Yang Ju , Yan Jing , Liu Baorui 

TITLE=Targeting VEGF/VEGFR to Modulate Antitumor Immunity

JOURNAL=Frontiers in Immunology

VOLUME=Volume 9 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.00978

DOI=10.3389/fimmu.2018.00978

ISSN=1664-3224

ABSTRACT=In addition to the crucial role in promoting the growth of tumor vessels, vascular endothelial growth factor (VEGF) is also immunosuppressive. VEGF can inhibit the function of T cells, increase the recruitment of regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), and hinder the differentiation and activation of dendritic cells (DCs). Recent studies have investigated the role of antiangiogenic agents in antitumor immunity, especially in recent three years. Therefore, it is necessary to update the role of targeting VEGF/VEGFR in anti-tumor immunity. In this review, we focus on the latest clinical and preclinical findings on the modulatory role of antiangiogenic agents targeting VEGF/VEGFR in immune cells, including effector T cells, Tregs, MDSCs, DCs, tumor-associated macrophages and mast cells. Our review will be potentially helpful for the development of combinations of angiogenesis inhibitors with immunological modulators.