AUTHOR=Peltier Daniel , Reddy Pavan 

TITLE=Non-Coding RNA Mediated Regulation of Allogeneic T Cell Responses After Hematopoietic Transplantation

JOURNAL=Frontiers in Immunology

VOLUME=Volume 9 - 2018

YEAR=2018

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.01110

DOI=10.3389/fimmu.2018.01110

ISSN=1664-3224

ABSTRACT=Allogeneic bone marrow transplantation (BMT) is an effective therapy for several malignant and non-malignant disorders.  The precise control of allogeneic T-cells is critical for successful outcomes after BMT.  The mechanisms governing desirable (graft versus leukemia) versus undesirable (graft versus host disease) allogeneic responses remain incompletely understood.   Non-coding RNAs (ncRNA) are controllers of gene expression that fine-tune cellular responses.  Multiple micro-RNAs (miRNA), a type of ncRNA, have recently been shown to influence allogeneic T cell responses in both murine models and clinically.  Here we review the role of various microRNAs that regulate T cell responses, either positively or negatively, to allo-stimulation and highlight their potential relevance as biomarkers and as therapeutic targets for improving outcomes after allogeneic BMT.